Pressure-induced expression changes in segmental flow regions of the human trabecular meshwork.
Janice A. Vranka,Ted S. Acott +1 more
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TL;DR: This work identified molecular expression differences between segmental flow regions of the TM from anterior segments perfused at either physiological or elevated pressure and found a limited subset of ECM genes is differentially regulated in both high and low flow regions and in response to elevated pressure.
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About: This article is published in Experimental Eye Research. The article was published on 01 May 2017. and is currently open access. The article focuses on the topics: Trabecular meshwork & Extracellular matrix.
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Matrix Metalloproteinases and Glaucoma Treatment.
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Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures
Janice A. Vranka,Julia Staverosky,Ashok P. Reddy,Phillip A. Wilmarth,Larry L. David,Ted S. Acott,Paul Russell,Vijay Krishna Raghunathan +7 more
TL;DR: Data show changes in biomechanical properties of segmental regions within the TM in response to elevated pressure, and levels of specific ECM proteins that are specifically involved in outflow resistance and IOP homeostasis.
69
Open-angle glaucoma: therapeutically targeting the extracellular matrix of the conventional outflow pathway.
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51
Characterization of Human Transition Zone Reveals a Putative Progenitor-Enriched Niche of Corneal Endothelium.
Gary Hin-Fai Yam,Xin-Yi Seah,Nur Zahirah Binte M Yusoff,Melina Setiawan,Stephen Wahlig,Hla Myint Htoon,Gary S L Peh,Gary S L Peh,Viridiana Kocaba,Jodhbir S. Mehta +9 more
TL;DR: A novel inner TZ containing progenitor-like cells is identified, which could serve the regenerative potential for corneal endothelium.
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Changes in gene expression by trabecular meshwork cells in response to mechanical stretching
TL;DR: The expression of a variety of TM genes is significantly affected by mechanical stretching, and several proteins that could contribute to the homeostatic modification of aqueous humor outflow resistance are also upregulated or downregulated.
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Intraocular pressure homeostasis: maintaining balance in a high-pressure environment
Ted S. Acott,Mary J. Kelley,Kate E. Keller,Janice A. Vranka,Diala W. Abu-Hassan,Xinbo Li,Mini Aga,John M. Bradley +7 more
TL;DR: It appears that the cells sense IOP elevations as mechanical stretch or distortion of the actual outflow resistance and respond by initiating a complex extracellular matrix (ECM) turnover process that takes several days to complete.
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