Pressure-induced expression changes in segmental flow regions of the human trabecular meshwork.
Janice A. Vranka,Ted S. Acott +1 more
48
TL;DR: This work identified molecular expression differences between segmental flow regions of the TM from anterior segments perfused at either physiological or elevated pressure and found a limited subset of ECM genes is differentially regulated in both high and low flow regions and in response to elevated pressure.
read more
About: This article is published in Experimental Eye Research. The article was published on 01 May 2017. and is currently open access. The article focuses on the topics: Trabecular meshwork & Extracellular matrix.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Normal and glaucomatous outflow regulation
TL;DR: A hypothetical model, based on considerable available data, posits that the continuous SCE basal lamina, which lies between 125 and 500 nm beneath the S CE basal surface, is the primary source of normal resistance and has the potential to advance the understanding of IOP regulation and of glaucoma.
120
Matrix Metalloproteinases and Glaucoma Treatment.
TL;DR: It is hypothesized that the higher concentrations of bimatoprost achieved in ocular outflow tissues with the implant produce greater MMP upregulation and more extensive, sustained MMP-mediated target tissue remodeling, providing an extended duration of effect.
86
Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures
Janice A. Vranka,Julia Staverosky,Ashok P. Reddy,Phillip A. Wilmarth,Larry L. David,Ted S. Acott,Paul Russell,Vijay Krishna Raghunathan +7 more
TL;DR: Data show changes in biomechanical properties of segmental regions within the TM in response to elevated pressure, and levels of specific ECM proteins that are specifically involved in outflow resistance and IOP homeostasis.
69
Open-angle glaucoma: therapeutically targeting the extracellular matrix of the conventional outflow pathway.
TL;DR: The role of ECM of the TM in outflow homeostasis and its relevance as a target for glaucoma therapy is discussed, including progress in development of topical eye formulations, together with gene therapy approaches based on inducible, virally-mediated expression of matrix metalloproteinases to enhance aqueous outflow.
51
Characterization of Human Transition Zone Reveals a Putative Progenitor-Enriched Niche of Corneal Endothelium.
Gary Hin-Fai Yam,Xin-Yi Seah,Nur Zahirah Binte M Yusoff,Melina Setiawan,Stephen Wahlig,Hla Myint Htoon,Gary S L Peh,Gary S L Peh,Viridiana Kocaba,Jodhbir S. Mehta +9 more
TL;DR: A novel inner TZ containing progenitor-like cells is identified, which could serve the regenerative potential for corneal endothelium.
45
References
Extracellular Matrix Turnover and Outflow Resistance
TL;DR: Recently identified podosome- or invadopodia-like structures (PILS) may aid in the focal degradation of ECM and organization of replacement components.
239
Scanning electron microscopic studies of the trabecular meshwork and the canal of Schlemm--an attempt to localize the main resistance to outflow of aqueous humor in man.
Anders Bill,Björn Svedbergh +1 more
TL;DR: Chamber angle tissue from human eyes was investigated with scanning electron microscopy and calculated that if all the observed pores exist in vivo, the resistance to outflow in the paths through the endothelial cells is a small fraction of the total resistance toOutflow.
227
Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells
TL;DR: Data on RhoA-induced changes in actomyosin contractile activity, ECM synthesis/assembly, and Erk activation, along with fibronectin-induced alpha-SMA expression in TM cells, reveal a potential molecular interplay between actomyOSin cytoskeletal tension and ECMhesis/assembly.
193
Reduction of the Available Area for Aqueous Humor Outflow and Increase in Meshwork Herniations into Collector Channels Following Acute IOP Elevation in Bovine Eyes
Stephanie A. Battista,Zhaozeng Lu,Zhaozeng Lu,Sara Hofmann,Thomas F. Freddo,Darryl R. Overby,Haiyan Gong,Haiyan Gong +7 more
TL;DR: Low outflow facility during acute IOP elevation coincides with a reduction in available area for aqueous humor outflow and the confinement of outflow to the vicinity of CC ostia, likely driven by morphologic changes associated with AP collapse and herniation of IW of AP intoCC ostia.
191