Pressure-induced expression changes in segmental flow regions of the human trabecular meshwork.
Janice A. Vranka,Ted S. Acott +1 more
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TL;DR: This work identified molecular expression differences between segmental flow regions of the TM from anterior segments perfused at either physiological or elevated pressure and found a limited subset of ECM genes is differentially regulated in both high and low flow regions and in response to elevated pressure.
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About: This article is published in Experimental Eye Research. The article was published on 01 May 2017. and is currently open access. The article focuses on the topics: Trabecular meshwork & Extracellular matrix.
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Citations
Normal and glaucomatous outflow regulation
TL;DR: A hypothetical model, based on considerable available data, posits that the continuous SCE basal lamina, which lies between 125 and 500 nm beneath the S CE basal surface, is the primary source of normal resistance and has the potential to advance the understanding of IOP regulation and of glaucoma.
120
Matrix Metalloproteinases and Glaucoma Treatment.
TL;DR: It is hypothesized that the higher concentrations of bimatoprost achieved in ocular outflow tissues with the implant produce greater MMP upregulation and more extensive, sustained MMP-mediated target tissue remodeling, providing an extended duration of effect.
86
Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures
Janice A. Vranka,Julia Staverosky,Ashok P. Reddy,Phillip A. Wilmarth,Larry L. David,Ted S. Acott,Paul Russell,Vijay Krishna Raghunathan +7 more
TL;DR: Data show changes in biomechanical properties of segmental regions within the TM in response to elevated pressure, and levels of specific ECM proteins that are specifically involved in outflow resistance and IOP homeostasis.
69
Open-angle glaucoma: therapeutically targeting the extracellular matrix of the conventional outflow pathway.
TL;DR: The role of ECM of the TM in outflow homeostasis and its relevance as a target for glaucoma therapy is discussed, including progress in development of topical eye formulations, together with gene therapy approaches based on inducible, virally-mediated expression of matrix metalloproteinases to enhance aqueous outflow.
51
Characterization of Human Transition Zone Reveals a Putative Progenitor-Enriched Niche of Corneal Endothelium.
Gary Hin-Fai Yam,Xin-Yi Seah,Nur Zahirah Binte M Yusoff,Melina Setiawan,Stephen Wahlig,Hla Myint Htoon,Gary S L Peh,Gary S L Peh,Viridiana Kocaba,Jodhbir S. Mehta +9 more
TL;DR: A novel inner TZ containing progenitor-like cells is identified, which could serve the regenerative potential for corneal endothelium.
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References
Extracellular matrix in the trabecular meshwork.
Ted S. Acott,Mary J. Kelley +1 more
TL;DR: Changes in ECM associated with open-angle glaucoma have been identified and several cytokines, growth factors and drugs, which affect the outflow resistance, change ECM component expression, mRNA alternative splicing, cellular cytoskeletal organization or all of these.
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What controls aqueous humour outflow resistance
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•Journal Article
Effect of matrix metalloproteinases activity on outflow in perfused human organ culture.
John M. Bradley,Janice A. Vranka,C. M. Colvis,D. M. Conger,J. P. Alexander,A. S. Fisk,John R. Samples,Ted S. Acott +7 more
TL;DR: Support is provided for the hypothesis that controlled extracellular matrix turnover is important in the regulation of aqueous humor outflow facility for trabecular outflow resistance in a human outflow model.
325
Current understanding of conventional outflow dysfunction in glaucoma.
W. Daniel Stamer,Ted S. Acott +1 more
TL;DR: The conventional outflow pathway is a dynamic, pressure-sensitive tissue that is vulnerable to pathology on many fronts, each representing a therapeutic opportunity.