Pressure-induced expression changes in segmental flow regions of the human trabecular meshwork.
Janice A. Vranka,Ted S. Acott +1 more
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TL;DR: This work identified molecular expression differences between segmental flow regions of the TM from anterior segments perfused at either physiological or elevated pressure and found a limited subset of ECM genes is differentially regulated in both high and low flow regions and in response to elevated pressure.
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About: This article is published in Experimental Eye Research. The article was published on 01 May 2017. and is currently open access. The article focuses on the topics: Trabecular meshwork & Extracellular matrix.
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Citations
Dexamethasone and Glucocorticoid-Induced Matrix Temporally Modulate Key Integrins, Caveolins, Contractility, and Stiffness in Human Trabecular Meshwork Cells
TL;DR: The authors' data highlight crucial mechanoreceptors, integrin adhesomes, and actin-related proteins that may temporally sustain fibrotic phenotypes precipitated by DEX and/or GIM in hTM cells.
Elevated pressure influences relative distribution of segmental regions of the trabecular meshwork.
TL;DR: The overall amount of MF regions is significantly increased in response to perfusion at elevated pressure during IOP homeostatic resistance adjustment, and the amount of both HF and LF regions was decreased accordingly suggesting a coordinated response in the TM to elevated pressure.
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Aqueous humour outflow imaging: seeing is believing.
Jong Yeon Lee,Jong Yeon Lee,Goichi Akiyama,Goichi Akiyama,Sindhu Saraswathy,Xiaobin Xie,Xiaobin Xie,Xiaojing Pan,Young-Kwon Hong,Alex S. Huang +9 more
TL;DR: New biological behaviours uncovered by modern imaging methods will be discussed with relevance to glaucoma therapies emphasized, and historical studies critical to understanding outflow anatomy will be presented.
A Naturally Fluorescent Mgp Transgenic Mouse for Angiogenesis and Glaucoma Longitudinal Studies.
TL;DR: The availability of a transgenic mouse naturally fluorescent inglaucoma-relevant tissues and retinal vasculature brings the unique opportunity to study a wide spectrum of single and combined glaucomatous conditions in vivo.
15
Ex-vivo cultured human corneoscleral segment model to study the effects of glaucoma factors on trabecular meshwork
TL;DR: The findings suggest that the ex-vivo cultured human corneoscleral segment model is cost-effective and can be used as a pre-screening tool to study the effects of glaucoma factors and anti-glaucomA therapeutics on the TM.
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