Claire Regazzetti
French Institute of Health and Medical Research
16 Papers
69 Citations
Claire Regazzetti is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Dopachrome tautomerase & Insulin. The author has an hindex of 11, co-authored 16 publications. Previous affiliations of Claire Regazzetti include University of Nice Sophia Antipolis.
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Papers
Melanocytes Sense Blue Light and Regulate Pigmentation through Opsin-3.
Claire Regazzetti,Laura Sormani,Delphine Debayle,Françoise Bernerd,Meri K. Tulic,Gian Marco De Donatis,B. Chignon-Sicard,Stéphane Rocchi,Thierry Passeron +8 more
TL;DR: Evidence is provided showing that OPN3 is the key sensor in melanocytes responsible for hyperpigmentation induced by the shorter wavelengths of visible light, and the multimeric tyrosinase/tyrosinases-related protein complex induced after its activation appears as new potential targets for regulating melanogenesis.
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Transcriptional Analysis of Vitiligo Skin Reveals the Alteration of WNT Pathway: A Promising Target for Repigmenting Vitiligo Patients
Claire Regazzetti,Florence Joly,Carine Marty,Michel Rivier,Bruno Mehul,Pascale Reiniche,Carine Mounier,Yves Rival,David Piwnica,M. Cavalié,B. Chignon-Sicard,Robert Ballotti,Johannes Voegel,Thierry Passeron +13 more
TL;DR: The results shed light on the previously unrecognized role of decreased WNT activation in the prevention of melanocyte differentiation in depigmented vitiligo skin and support further clinical exploration of WNT agonists to repigment Vitiligo lesions.
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Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo
Meri K. Tulic,Elisa Cavazza,Yann Cheli,Arnaud Jacquel,Carmelo Luci,Nathalie Cardot-Leccia,Hanene Hadhiri-Bzioueche,Patricia Abbe,Maeva Gesson,Laura Sormani,Claire Regazzetti,Guillaume E. Beranger,Cedric Lereverend,Caroline Pons,Abdallah Khemis,Robert Ballotti,Corine Bertolotto,Stéphane Rocchi,Thierry Passeron +18 more
TL;DR: NK and ILC1 cells are increased in vitiligo patients, and induce melanocyte apoptosis via CXCR3B, which in turn leads to increased priming of T cell responses in cell culture.
Endothelial Cells Promote Pigmentation through Endothelin Receptor B Activation
Claire Regazzetti,Gian Marco De Donatis,Houda Hammami Ghorbel,Nathalie Cardot-Leccia,Damien Ambrosetti,Philippe Bahadoran,B. Chignon-Sicard,Jean-Philippe Lacour,Robert Ballotti,Andre Mahns,Thierry Passeron +10 more
TL;DR: The role of underlying microvascularization in skin pigmentation is demonstrated, a finding that could open new fields of research for regulating physiological pigmentation and for treating pigmentation disorders such as melasma.
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Inhibition of Melanogenesis by the Antidiabetic Metformin
Abdelali Lehraiki,Abdelali Lehraiki,Patricia Abbe,Patricia Abbe,Michael Cerezo,Michael Cerezo,Florian Rouaud,Florian Rouaud,Claire Regazzetti,Claire Regazzetti,B. Chignon-Sicard,Thierry Passeron,Thierry Passeron,Corine Bertolotto,Corine Bertolotto,Robert Ballotti,Robert Ballotti,Stéphane Rocchi,Stéphane Rocchi +18 more
TL;DR: It is shown that metformin led to reduced melanin content in melanoma cells and in normal human melanocytes by decreasing cAMP accumulation and cAMP-responsive element-binding protein phosphorylation, and it is demonstrated that the antimelanogenic effect of met formin is independent of the AMPK pathway.
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