Maeva Gesson
French Institute of Health and Medical Research
11 Papers
19 Citations
Maeva Gesson is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Melanoma & Cancer cell. The author has an hindex of 6, co-authored 10 publications.
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Papers
Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo
Meri K. Tulic,Elisa Cavazza,Yann Cheli,Arnaud Jacquel,Carmelo Luci,Nathalie Cardot-Leccia,Hanene Hadhiri-Bzioueche,Patricia Abbe,Maeva Gesson,Laura Sormani,Claire Regazzetti,Guillaume E. Beranger,Cedric Lereverend,Caroline Pons,Abdallah Khemis,Robert Ballotti,Corine Bertolotto,Stéphane Rocchi,Thierry Passeron +18 more
TL;DR: NK and ILC1 cells are increased in vitiligo patients, and induce melanocyte apoptosis via CXCR3B, which in turn leads to increased priming of T cell responses in cell culture.
Development of highly sensitive fluorescent probes for the detection of β-galactosidase activity – application to the real-time monitoring of senescence in live cells
TL;DR: βGal-1 exhibited an extremely fast response and over 200-fold fluorescence enhancement following the enzymatic cleavage of the β-d-galactopyranoside unit, which allowed the detection of senescence-associated β-Galactosidase (SA-β-gal) activity; a widely used biomarker ofsenescence.
UBTD1 is a mechano-regulator controlling cancer aggressiveness.
Stéphanie Torrino,François-René Roustan,Lisa Kaminski,Thomas Bertero,Sabrina Pisano,Damien Ambrosetti,Maeva Dufies,Jay P. Uhler,Emmanuel Lemichez,Amel Mettouchi,Maeva Gesson,Kathiane Laurent,Cedric Gaggioli,Jean-François Michiels,Christophe Lamaze,Frédéric Bost,Stephan Clavel +16 more
TL;DR: It is demonstrated that depletion of UBTD1 drastically affects the mechanical properties of epithelial cancer cells via RhoA activation and strongly promotes their aggressiveness, and data from lung and prostate cancer patients further corroborate the in cellulo results, confirming that low levels of UbtD1 are associated with poor patient survival, suggesting that biological functions of U BTD1 could be beneficial in limiting cancer progression.
PGC1α Inhibits Polyamine Synthesis to Suppress Prostate Cancer Aggressiveness.
Lisa Kaminski,Stéphanie Torrino,Maeva Dufies,Zied Djabari,Romain Haider,Francois Rene Roustan,Francois Rene Roustan,Emilie Jaune,Kathiane Laurent,Nicolas Nottet,J. F. Michiels,Maeva Gesson,Stéphane Rocchi,Nathalie M. Mazure,Matthieu Durand,Jean-François Tanti,Damien Ambrosetti,Stephan Clavel,Issam Ben-Sahra,Frédéric Bost +19 more
TL;DR: Downregulation of PGC-1α renders PCa cells dependent on polyamine to promote metastasis, and analysis of in vivo metastases and clinical data from prostate cancer patients support the proposition that the P GC-1 α/c-MYC/ODC1 axis regulates polyamine biosynthesis and prostate cancer aggressiveness.
Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies.
Emilie Jaune,Elisa Cavazza,Cyril Ronco,Oleksandr Grytsai,Patricia Abbe,Nedra Tekaya,Marwa Zerhouni,Guillaume E. Beranger,Lisa Kaminski,Frédéric Bost,Maeva Gesson,Meri K. Tulic,Paul Hofman,Paul Hofman,Robert Ballotti,Thierry Passeron,Thomas Botton,Rachid Benhida,Stéphane Rocchi +18 more
TL;DR: In this article, biguanide-derived molecules against melanoma were discovered and developed and identified the promising new compound CRO15, which exerted anti-melanoma effects on cells lines and cells isolated from patients including the ones derived from tumors resistant to BRAF inhibitors.