Gian Marco De Donatis
French Institute of Health and Medical Research
20 Papers
231 Citations
Gian Marco De Donatis is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Binding site & Internal medicine. The author has an hindex of 13, co-authored 18 publications. Previous affiliations of Gian Marco De Donatis include National Institutes of Health & University of Pisa.
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Papers
Melanocytes Sense Blue Light and Regulate Pigmentation through Opsin-3.
Claire Regazzetti,Laura Sormani,Delphine Debayle,Françoise Bernerd,Meri K. Tulic,Gian Marco De Donatis,B. Chignon-Sicard,Stéphane Rocchi,Thierry Passeron +8 more
TL;DR: Evidence is provided showing that OPN3 is the key sensor in melanocytes responsible for hyperpigmentation induced by the shorter wavelengths of visible light, and the multimeric tyrosinase/tyrosinases-related protein complex induced after its activation appears as new potential targets for regulating melanogenesis.
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Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance
Camila Rubio-Patiño,Jozef P. Bossowski,Gian Marco De Donatis,Laura Mondragón,Elodie Villa,Lazaro Emilio Aira,Johanna Chiche,Rana Mhaidly,Cynthia Lebeaupin,Sandrine Marchetti,Konstantinos Voutetakis,Aristotelis Chatziioannou,Florence Castelli,Patricia Lamourette,Emeline Chu-Van,François Fenaille,Tony Avril,Thierry Passeron,John B. Patterson,Els Verhoeyen,Béatrice Bailly-Maitre,Eric Chevet,Jean-Ehrland Ricci +22 more
TL;DR: It is demonstrated that feeding mice a low-protein (Low PROT) isocaloric diet but not aLow CHO diet reduced tumor growth in three independent mouse cancer models, suggesting that a Low PROT diet induces an IRE1α-dependent UPR in cancer cells, enhancing a CD8-mediated T cell response against tumors.
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Endothelial Cells Promote Pigmentation through Endothelin Receptor B Activation
Claire Regazzetti,Gian Marco De Donatis,Houda Hammami Ghorbel,Nathalie Cardot-Leccia,Damien Ambrosetti,Philippe Bahadoran,B. Chignon-Sicard,Jean-Philippe Lacour,Robert Ballotti,Andre Mahns,Thierry Passeron +10 more
TL;DR: The role of underlying microvascularization in skin pigmentation is demonstrated, a finding that could open new fields of research for regulating physiological pigmentation and for treating pigmentation disorders such as melasma.
112
Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber
Sun Shin Cha,Sun Shin Cha,Young Jun An,Chang-Ro Lee,Hyun Sook Lee,Yeon Gil Kim,Sang-Jin Kim,Sang-Jin Kim,Kae Kyoung Kwon,Kae Kyoung Kwon,Gian Marco De Donatis,Jung-Hyun Lee,Jung-Hyun Lee,Michael R. Maurizi,Sung Gyun Kang,Sung Gyun Kang +15 more
TL;DR: The 2.0‐Å resolution crystal structure of Thermococcus onnurineus NA1 Lon (TonLon), a tandem fusion of an AAA+ molecular chaperone and a protease with a serine‐lysine catalytic dyad, is reported.
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Revolution rather than rotation of AAA+ hexameric phi29 nanomotor for viral dsDNA packaging without coiling.
TL;DR: A revolution rather than rotation mechanism for the bacteriophage phi29 DNA packaging motor might reconcile the stoichiometry discrepancy in many phage systems where the ATPase has been found as a tetramer, hexamer, or nonamer.
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