Shanshan Zhang
University of California, San Francisco
44 Papers
125 Citations
Shanshan Zhang is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Autophagy & Mesenchymal stem cell. The author has an hindex of 24, co-authored 42 publications. Previous affiliations of Shanshan Zhang include Second Military Medical University & Ruijin Hospital.
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Papers
Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells
Xianling Guo,Ding Li,Fei Hu,Jianrui Song,Shanshan Zhang,Wei-jie Deng,Kai Sun,Qiudong Zhao,Xuqin Xie,Yu-jiao Song,Mengchao Wu,Lixin Wei +11 more
TL;DR: It is suggested that autophagy is a potential novel target to improve therapy efficiency of conventional chemotherapeutics towards HCC.
181
CD133 + CXCR4 + colon cancer cells exhibit metastatic potential and predict poor prognosis of patients
Shanshan Zhang,Zhipeng Han,Ying Ying Jing,Shuang-fen Tao,Tie-Jun Li,Hao-Hao Wang,Yang Wang,Rong Li,Yang Yang,Xue Zhao,Xiao-dong Xu,En-Da Yu,Rui Yaocheng,Hou-jia Liu,Li-Li Zhang,Lixin Wei +15 more
TL;DR: It was found that CD133+CXCR4+ cancer cells had a high metastatic capacity in vitro and in vivo, and strategies targeting the SDF-1/CX CR4 interaction may have important clinical applications in the suppression of colon cancer metastasis.
169
Autophagy contributes to the survival of CD133+ liver cancer stem cells in the hypoxic and nutrient-deprived tumor microenvironment
Yu-jiao Song,Shanshan Zhang,Xianling Guo,Kai Sun,Zhipeng Han,Rong Li,Qiudong Zhao,Wei-jie Deng,Xuqin Xie,Jian-wei Zhang,Mengchao Wu,Lixin Wei +11 more
TL;DR: It is shown that CD133+ cells were significantly enriched after hypoxia and nutrient starvation (H/S) in the human HCC cell line Huh7, and autophagy inhibitors may make LCSCs more sensitive to the tumor microenvironment and be useful in improving anti-cancer treatments.
163
Autophagy prevents irradiation injury and maintains stemness through decreasing ROS generation in mesenchymal stem cells
Jing Hou,Zhipeng Han,Yingying Jing,X Yang,Shanshan Zhang,Kai Sun,Chong Hao,Yan Meng,Fenghai Yu,Xi Liu,Yufang Shi,Mengchao Wu,Lei Zhang,Lixin Wei +13 more
TL;DR: It is demonstrated that irradiation could induce reactive oxygen species (ROS) accumulation that resulted in DNA damage and stemness injury in MSCs and indicated that autophagy may have an important role in protecting stemness of M SCs from irradiation injury.
Toll-like receptor 4 signaling promotes epithelial-mesenchymal transition in human hepatocellular carcinoma induced by lipopolysaccharide
Yingying Jing,Zhipeng Han,Kai Sun,Shanshan Zhang,Jing Hou,Yan Liu,Rong Li,Lu Gao,Xue Zhao,Qiudong Zhao,Mengchao Wu,Lixin Wei +11 more
TL;DR: It is found that TLR4 signaling is required for LPS-induced EMT, tumor cell invasion and metastasis, which provide molecular insights for L PS-related pathogenesis and a basis for developing new strategies against metastasis in HCC.