33 Papers
116 Citations
Kai Sun is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Autophagy & Apoptosis. The author has an hindex of 24, co-authored 32 publications. Previous affiliations of Kai Sun include Second Military Medical University.
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Papers
Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells
Xianling Guo,Ding Li,Fei Hu,Jianrui Song,Shanshan Zhang,Wei-jie Deng,Kai Sun,Qiudong Zhao,Xuqin Xie,Yu-jiao Song,Mengchao Wu,Lixin Wei +11 more
TL;DR: It is suggested that autophagy is a potential novel target to improve therapy efficiency of conventional chemotherapeutics towards HCC.
181
Autophagy contributes to the survival of CD133+ liver cancer stem cells in the hypoxic and nutrient-deprived tumor microenvironment
Yu-jiao Song,Shanshan Zhang,Xianling Guo,Kai Sun,Zhipeng Han,Rong Li,Qiudong Zhao,Wei-jie Deng,Xuqin Xie,Jian-wei Zhang,Mengchao Wu,Lixin Wei +11 more
TL;DR: It is shown that CD133+ cells were significantly enriched after hypoxia and nutrient starvation (H/S) in the human HCC cell line Huh7, and autophagy inhibitors may make LCSCs more sensitive to the tumor microenvironment and be useful in improving anti-cancer treatments.
163
High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients
Xiaojing Chen,Kai Sun,Shufan Jiao,Ning Cai,Xue Zhao,Hanbing Zou,Yuexia Xie,Zhengshi Wang,Ming Zhong,Lixin Wei +9 more
TL;DR: SIRT1 is a potential independent prognostic factor of CRC patients after tumor resection with curative intent, and will contribute to providing a promising new approach to target at CSCs in CRC treatment.
Autophagy prevents irradiation injury and maintains stemness through decreasing ROS generation in mesenchymal stem cells
Jing Hou,Zhipeng Han,Yingying Jing,X Yang,Shanshan Zhang,Kai Sun,Chong Hao,Yan Meng,Fenghai Yu,Xi Liu,Yufang Shi,Mengchao Wu,Lei Zhang,Lixin Wei +13 more
TL;DR: It is demonstrated that irradiation could induce reactive oxygen species (ROS) accumulation that resulted in DNA damage and stemness injury in MSCs and indicated that autophagy may have an important role in protecting stemness of M SCs from irradiation injury.
The role of autophagy induced by tumor microenvironment in different cells and stages of cancer.
TL;DR: The interaction between Autophagy and the tumor microenvironment and the paradoxical roles of autophagy on tumor growth at different stages of tumor development are discussed.