Elmar Bucher
Oregon Health & Science University
15 Papers
13 Citations
Elmar Bucher is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Tumor microenvironment & Population. The author has an hindex of 5, co-authored 15 publications.
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Papers
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
Alexandra B Keenan,Sherry L. Jenkins,Kathleen M. Jagodnik,Simon Koplev,Edward He,Denis Torre,Zichen Wang,Anders B. Dohlman,Moshe C. Silverstein,Alexander Lachmann,Maxim V. Kuleshov,Avi Ma'ayan,Vasileios Stathias,Raymond Terryn,Daniel J. Cooper,Michele Forlin,Amar Koleti,Dusica Vidovic,Caty Chung,Stephan C. Schürer,Jouzas Vasiliauskas,Marcin Pilarczyk,Behrouz Shamsaei,Mehdi Fazel,Yan Ren,Wen Niu,Nicholas A. Clark,Shana White,Naim Al Mahi,Lixia Zhang,Michal Kouril,John F. Reichard,Siva Sivaganesan,Mario Medvedovic,Jaroslaw Meller,Rick J. Koch,Marc R. Birtwistle,Ravi Iyengar,Eric A. Sobie,Evren U. Azeloglu,Julia A. Kaye,Jeannette Osterloh,Kelly Haston,Jaslin Kalra,Steve Finkbiener,Jonathan Z. Li,Pamela Milani,Miriam Adam,Renan Escalante-Chong,Karen Sachs,Alexander LeNail,Divya Ramamoorthy,Ernest Fraenkel,Gavin Daigle,Uzma Hussain,Alyssa Coye,Jeffrey D. Rothstein,Dhruv Sareen,Loren Ornelas,Maria G. Banuelos,Berhan Mandefro,Ritchie Ho,Clive N. Svendsen,Ryan G. Lim,Jennifer Stocksdale,Malcolm Casale,Terri G. Thompson,Jie Wu,Leslie M. Thompson,Victoria Dardov,Vidya Venkatraman,Andrea Matlock,Jennifer E. Van Eyk,Jacob D. Jaffe,Malvina Papanastasiou,Aravind Subramanian,Todd R. Golub,Sean D. Erickson,Mohammad Fallahi-Sichani,Marc Hafner,Nathanael S. Gray,Jia-Ren Lin,Caitlin E. Mills,Jeremy L. Muhlich,Mario Niepel,Caroline E. Shamu,Elizabeth H. Williams,David Wrobel,Peter K. Sorger,Laura M. Heiser,Joe W. Gray,James E. Korkola,Gordon B. Mills,Mark A. LaBarge,Mark A. LaBarge,Heidi S. Feiler,Mark A. Dane,Elmar Bucher,Michel Nederlof,Damir Sudar,Sean M. Gross,David Kilburn,Rebecca Smith,Kaylyn Devlin,Ron Margolis,Leslie Derr,Albert Lee,Ajay Pillai +107 more
TL;DR: The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders.
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Enzalutamide response in a panel of prostate cancer cell lines reveals a role for glucocorticoid receptor in enzalutamide resistant disease.
Rebecca Smith,Moqing Liu,Tiera Liby,Nora Bayani,Elmar Bucher,Kami E. Chiotti,Daniel S. Derrick,Anne Chauchereau,Laura M. Heiser,Joshi J. Alumkal,Joshi J. Alumkal,Heidi S. Feiler,Peter R. Carroll,James E. Korkola +13 more
TL;DR: This study reinforces the utility of large cell line panels for the study of cancer and identifies several cell lines that represent ideal models to study AR-null cells that have upregulated GR to sustain growth.
Individual Cells Can Resolve Variations in Stimulus Intensity along the IGF-PI3K-AKT Signaling Axis.
TL;DR: The rational development of a genetically encoded FoxO1 sensor is described, which serves as a down-stream readout of insulin growth factor-phosphatidylinositol 3-kinase IGF-PI3K-AKT signaling pathway activity, and these responses are sustained over time, reproducible at the single-cell level, and display cell-to-cell heterogeneity.
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The impact of tumor epithelial and microenvironmental heterogeneity on treatment responses in HER2+ breast cancer
Michalina Janiszewska,Michalina Janiszewska,Michalina Janiszewska,Shayna Stein,Otto Metzger Filho,Otto Metzger Filho,Jennifer Eng,Natalie L. Kingston,Nicholas W. Harper,Inga H. Rye,Maša Alečković,Maša Alečković,Anne Trinh,Anne Trinh,Katherine Murphy,Elisabetta Marangoni,Simona Cristea,Benjamin Oakes,Eric P. Winer,Eric P. Winer,Ian E. Krop,Hege G. Russnes,Paul T. Spellman,Elmar Bucher,Zhi Hu,Koei Chin,Joe W. Gray,Franziska Michor,Kornelia Polyak +28 more
TL;DR: In this paper, the effect of intratumor cellular genetic heterogeneity for ERBB2 (encoding HER2) copy number and PIK3CA mutation on different types of neoadjuvant HER2-targeting therapies and clinical outcome in HER2+ breast cancer was investigated.
A LINCS microenvironment perturbation resource for integrative assessment of ligand-mediated molecular and phenotypic responses
Sean M. Gross,Mark A. Dane,Rebecca Smith,Kaylyn Devlin,Ian McLean,Daniel S. Derrick,Caitlin E. Mills,Kartik Subramanian,Alexandra B K London,Denis Torre,Cemal Erdem,Nicholas J. Lyons,Ted Natoli,Sarah Pessa,Xiaodong Lu,James Mullahoo,Jonathan Z. Li,Miriam Adam,Brook T. Wassie,Moqing Liu,David Kilburn,Tiera Liby,Elmar Bucher,Crystal Sanchez-Aguila,Kenneth Daily,Larsson Omberg,Yunguan Wang,Connor A. Jacobson,Clarence Yapp,Mirra Chung,Dusica Vidovic,Yiling Lu,Stephan C. Schürer,Albert Lee,Ajay S. Pillai,Aravind Subramanian,Malvina Papanastasiou,Ernest Fraenkel,Heidi S. Feiler,Gordon B. Mills,Jake Jaffe,Avi Ma'ayan,Marc R. Birtwistle,Peter K. Sorger,James E. Korkola,Joe W. Gray,Laura M. Heiser +46 more
TL;DR: In this article, the authors generated a comprehensive dataset that catalogs the transcriptional, proteomic, epigenomic and phenotypic responses of MCF10A mammary epithelial cells after exposure to the ligands EGF, HGF, OSM, IFNG, TGFB and BMP2.