Mark A. Dane

TL;DR: In this article , a multi-encoder VAE (ME-VAE) was proposed for single cell image analysis using transformed images as a self-supervised signal to extract transform-invariant biologically meaningful features.

TL;DR: The rational development of a genetically encoded FoxO1 sensor is described, which serves as a down-stream readout of insulin growth factor-phosphatidylinositol 3-kinase IGF-PI3K-AKT signaling pathway activity, and these responses are sustained over time, reproducible at the single-cell level, and display cell-to-cell heterogeneity.

TL;DR: A molecular signature which may guide therapeutic approaches for tumors with high mitotic network activity is defined and 22 genes that might be considered as additional therapeutic targets for this clinically relevant patient subgroup are identified.

TL;DR: In this paper , a linear chain trick (LCT) computational model was used to capture drug-induced dynamic responses, correctly infers drug effects, and reproduces influences on specific cell cycle phases.