David Wrobel
Harvard University
6 Papers
David Wrobel is an academic researcher from Harvard University. The author has contributed to research in topics: Computer science & Controlled vocabulary. The author has an hindex of 4, co-authored 4 publications.
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Papers
Statistical methods for analysis of high-throughput RNA interference screens
Amanda Birmingham,Laura M. Selfors,Thorsten Forster,David Wrobel,Caleb J. Kennedy,Emma Shanks,Javier Santoyo-Lopez,Dara J. Dunican,Aideen Long,Dermot Kelleher,Queta Smith,Roderick L. Beijersbergen,Peter Ghazal,Caroline E. Shamu +13 more
TL;DR: This work examines the similarities and differences between RNAi and small-molecule screens, highlighting particular characteristics of RNAi screen data that must be addressed during analysis and provides guidance on selection of analysis techniques in the context of a sample workflow.
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
Alexandra B Keenan,Sherry L. Jenkins,Kathleen M. Jagodnik,Simon Koplev,Edward He,Denis Torre,Zichen Wang,Anders B. Dohlman,Moshe C. Silverstein,Alexander Lachmann,Maxim V. Kuleshov,Avi Ma'ayan,Vasileios Stathias,Raymond Terryn,Daniel J. Cooper,Michele Forlin,Amar Koleti,Dusica Vidovic,Caty Chung,Stephan C. Schürer,Jouzas Vasiliauskas,Marcin Pilarczyk,Behrouz Shamsaei,Mehdi Fazel,Yan Ren,Wen Niu,Nicholas A. Clark,Shana White,Naim Al Mahi,Lixia Zhang,Michal Kouril,John F. Reichard,Siva Sivaganesan,Mario Medvedovic,Jaroslaw Meller,Rick J. Koch,Marc R. Birtwistle,Ravi Iyengar,Eric A. Sobie,Evren U. Azeloglu,Julia A. Kaye,Jeannette Osterloh,Kelly Haston,Jaslin Kalra,Steve Finkbiener,Jonathan Z. Li,Pamela Milani,Miriam Adam,Renan Escalante-Chong,Karen Sachs,Alexander LeNail,Divya Ramamoorthy,Ernest Fraenkel,Gavin Daigle,Uzma Hussain,Alyssa Coye,Jeffrey D. Rothstein,Dhruv Sareen,Loren Ornelas,Maria G. Banuelos,Berhan Mandefro,Ritchie Ho,Clive N. Svendsen,Ryan G. Lim,Jennifer Stocksdale,Malcolm Casale,Terri G. Thompson,Jie Wu,Leslie M. Thompson,Victoria Dardov,Vidya Venkatraman,Andrea Matlock,Jennifer E. Van Eyk,Jacob D. Jaffe,Malvina Papanastasiou,Aravind Subramanian,Todd R. Golub,Sean D. Erickson,Mohammad Fallahi-Sichani,Marc Hafner,Nathanael S. Gray,Jia-Ren Lin,Caitlin E. Mills,Jeremy L. Muhlich,Mario Niepel,Caroline E. Shamu,Elizabeth H. Williams,David Wrobel,Peter K. Sorger,Laura M. Heiser,Joe W. Gray,James E. Korkola,Gordon B. Mills,Mark A. LaBarge,Mark A. LaBarge,Heidi S. Feiler,Mark A. Dane,Elmar Bucher,Michel Nederlof,Damir Sudar,Sean M. Gross,David Kilburn,Rebecca Smith,Kaylyn Devlin,Ron Margolis,Leslie Derr,Albert Lee,Ajay Pillai +107 more
TL;DR: The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders.
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Metadata standard and data exchange specifications to describe, model, and integrate complex and diverse high-throughput screening data from the library of integrated network-based cellular signatures (LINCS)
Uma D. Vempati,Caty Chung,Christopher C. Mader,Amar Koleti,Nakul Datar,Dusica Vidovic,David Wrobel,Sean D. Erickson,Jeremy L. Muhlich,Gabriel F. Berriz,Cyril H. Benes,Aravind Subramanian,Ajay S. Pillai,Caroline E. Shamu,Stephan C. Schürer +14 more
TL;DR: In this paper, the authors present metadata specifications for the most important molecular and cellular components and recommend them for adoption beyond the National Institutes of Health Library of Integrated Network-based Cellular Signatures (LINCS) program.
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Screensaver: an open source lab information management system (LIMS) for high throughput screening facilities
Andrew N. Tolopko,John P Sullivan,John P Sullivan,Sean D. Erickson,David Wrobel,Su L Chiang,Katrina Rudnicki,Stewart Rudnicki,Jennifer Nale,Laura M. Selfors,Dara Greenhouse,Jeremy L. Muhlich,Caroline E. Shamu +12 more
TL;DR: The informatics and administrative needs of an HTS facility may be best managed by a single, integrated, web-accessible application such as Screensaver, which has proven useful in meeting the requirements of the ICCB-Longwood/NSRB Screening Facility at Harvard Medical School.
Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells
Wenyang Li,Robert P. Sparks,Chengbo Sun,Yang Yang,Lorena Pantano,Rory Kirchner,Jennifer Y. Chen,Sean P. Moran,Victor Barrera,David Wrobel,Shannan J. Ho Sui,Gary Erik Aspnes,Michael Schuler,Jennifer A. Smith,Benjamin D. Medoff,Carine M. Boustany-Kari,Jörg F. Rippmann,Daniela M. Santos,Julia F. Doerner,Alan C. Mullen +19 more
TL;DR: A high-throughput small interfering RNA screen in primary human HSC myofibroblasts targeting RNAs from >9,500 genes to identify those that promote the fibrotic phenotype of HSCs identified ABHD17B (Abhydrolase domain containing 17B, depalmitoylase), which may have potential as an antifibrotic therapy.