Yinglu Cui
Chinese Academy of Sciences
42 Papers
111 Citations
Yinglu Cui is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Chemistry & Catalysis. The author has an hindex of 13, co-authored 35 publications. Previous affiliations of Yinglu Cui include University of Minnesota & Jilin University.
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Papers
Computational Redesign of a PETase for Plastic Biodegradation under Ambient Condition by the GRAPE Strategy
Yinglu Cui,Yanchun Chen,Xinyue Liu,Xinyue Liu,Saijun Dong,Yu’e Tian,Yuxin Qiao,Ruchira Mitra,Jing Han,Chunli Li,Xu Han,Weidong Liu,Quan Chen,Wangqing Wei,Xin Wang,Wenbin Du,Shuangyan Tang,Hua Xiang,Haiyan Liu,Yong Liang,Kendall N. Houk,Bian Wu +21 more
TL;DR: A large number of enzymes, including those responsible for essential biochemical functions but not usually suitable for technological applications, have been found to be suitable for agricultural applications.
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Computational redesign of enzymes for regio- and enantioselective hydroamination.
Ruifeng Li,Hein J. Wijma,Lu Song,Yinglu Cui,Marleen Otzen,Yu’e Tian,Jiawei Du,Tao Li,Dingding Niu,Yanchun Chen,Jing Feng,Jian Han,Hao Chen,Yong Tao,Dick B. Janssen,Bian Wu +15 more
TL;DR: Computational protein design, without subsequent directed evolution, rapidly provides a set of aspartase variants capable of biocatalytic asymmetric addition of ammonia to substituted acrylates, producing various enantiopure β-amino acids.
Cryptococcus neoformans sexual reproduction is controlled by a quorum sensing peptide
Xiuyun Tian,Guang-Jun He,Pengjie Hu,Lei Chen,Changyu Tao,Yinglu Cui,Lan Shen,Weixin Ke,Haijiao Xu,Youbao Zhao,Qijiang Xu,Feng-Yan Bai,Bian Wu,Ence Yang,Xiaorong Lin,Linqi Wang +15 more
TL;DR: Quorum sensing (QS) is shown to control eukaryotic-specific behaviours and the atypical zinc finger regulator Cqs2 is identified as an important component of the Qsp1 signalling cascade during both bisexual and unisexual reproduction, extending the range of behaviours governed by quorum sensing to sexual development and meiosis.
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Development of a versatile and efficient C–N lyase platform for asymmetric hydroamination via computational enzyme redesign
Yinglu Cui,Yinghui Wang,Yinghui Wang,Wenya Tian,Yifan Bu,Tao Li,Xuexian Cui,Tong Zhu,Ruifeng Li,Bian Wu +9 more
- 01 May 2021
TL;DR: The computational redesign of aspartase is reported, a highly specific ammonia lyase, to yield C-N lyases with unprecedented cross-compatibility of nonnative nucleophiles and electrophiles, which supports the preparation of diverse libraries of ncAAs and their derivatives and will present opportunities in medicinal chemistry and synthetic biology.
Engineering improved thermostability of the GH11 xylanase from Neocallimastix patriciarum via computational library design
TL;DR: This study used in silico design in a glycoside hydrolase family (GH) 11 xylanase to stabilize the enzyme and constructed a variant that can be used as an efficient biocatalyst for XOS production at industrially viable conditions.
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