Xian Wang
Peking University
186 Papers
1K Citations
Xian Wang is an academic researcher from Peking University. The author has contributed to research in topics: Internal medicine & Calcitonin gene-related peptide. The author has an hindex of 46, co-authored 171 publications. Previous affiliations of Xian Wang include Chinese Ministry of Education.
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Papers
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.
Lulu Sun,Cen Xie,Guang Wang,Yue Wu,Qing Wu,Xuemei Wang,Jia Liu,Yangyang Deng,Jialin Xia,Bo Chen,Song-Yang Zhang,Chuyu Yun,Guan Lian,Xiujuan Zhang,Heng Zhang,William H. Bisson,Jingmin Shi,Xiaoxia Gao,Pupu Ge,Cui Hua Liu,Kristopher W. Krausz,Robert G. Nichols,Jingwei Cai,Bipin Rimal,Andrew D. Patterson,Xian Wang,Frank J. Gonzalez,Changtao Jiang +27 more
TL;DR: It is concluded that metformin acts in part through a B. fragilis–GUDCA–intestinal FXR axis to improve metabolic dysfunction, including hyperglycemia, and improves the metabolic health of humans and mice.
843
Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial.
Yong Huo,Jianping Li,Xianhui Qin,Xianhui Qin,Yining Huang,Xiaobin Wang,Rebecca F. Gottesman,Rebecca F. Gottesman,Genfu Tang,Binyan Wang,Binyan Wang,Dafang Chen,Mingli He,Jia Fu,Yefeng Cai,Xiuli Shi,Yan Zhang,Yimin Cui,Ningling Sun,Xiaoying Li,Xiaoshu Cheng,Jian’an Wang,Xinchun Yang,Tianlun Yang,Chuanshi Xiao,Gang Zhao,Qiang Dong,Dingliang Zhu,Xian Wang,Junbo Ge,Lianyou Zhao,Dayi Hu,Lisheng Liu,Fan Fan Hou +33 more
TL;DR: Among adults with hypertension in China without a history of stroke or MI, the combined use of enalapril and folic acid, compared with en alapril alone, significantly reduced the risk of first stroke.
HIF1α-Induced Glycolysis Metabolism Is Essential to the Activation of Inflammatory Macrophages.
TL;DR: It is indicated that HIF1α promoted macrophage glycolysis metabolism, which induced M1 polarization in mice, and was via upregulating the mRNA expression of the genes related to the glycoleysis metabolism.
Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury
Tuoyi Li,Tuoyi Li,Bing Yu,Zhixin Liu,Jingyuan Li,Ming-Liang Ma,Yingbao Wang,Mingjiang Zhu,Huiyong Yin,Xiaofeng Wang,Yi Fu,Fang Yu,Xian Wang,Xiaohong Fang,Jin-Peng Sun,Jin-Peng Sun,Wei Kong +16 more
TL;DR: It is found that homocysteine aggravates vascular injury by direct binding to the angiotensin II type 1 receptor (AT1R), identifying AT1R inhibition as a potential strategy to counteract the deleterious vascular effects of hyperhomocysteinemia.
ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-Injured Rat Arteries
Li Wang,Jingang Zheng,Xue Bai,Bo Liu,Chuan-ju Liu,Qingbo Xu,Yi Zhu,Nanping Wang,Wei Kong,Xian Wang +9 more
TL;DR: Enforced expression of COMP significantly suppressed VSMC migration and neointima formation postinjury, which indicates that ADAMTS-7 facilitated intimal hyperplasia through degradation of inhibitory matrix protein COMP.
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