Kristopher W. Krausz
National Institutes of Health
220 Papers
1.5K Citations
Kristopher W. Krausz is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 61, co-authored 201 publications. Previous affiliations of Kristopher W. Krausz include Pennsylvania State University.
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Papers
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.
Lulu Sun,Cen Xie,Guang Wang,Yue Wu,Qing Wu,Xuemei Wang,Jia Liu,Yangyang Deng,Jialin Xia,Bo Chen,Song-Yang Zhang,Chuyu Yun,Guan Lian,Xiujuan Zhang,Heng Zhang,William H. Bisson,Jingmin Shi,Xiaoxia Gao,Pupu Ge,Cui Hua Liu,Kristopher W. Krausz,Robert G. Nichols,Jingwei Cai,Bipin Rimal,Andrew D. Patterson,Xian Wang,Frank J. Gonzalez,Changtao Jiang +27 more
TL;DR: It is concluded that metformin acts in part through a B. fragilis–GUDCA–intestinal FXR axis to improve metabolic dysfunction, including hyperglycemia, and improves the metabolic health of humans and mice.
843
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
Fei Li,Changtao Jiang,Kristopher W. Krausz,Yunfei Li,Istvan Albert,Haiping Hao,Kristin M. Fabre,James B. Mitchell,Andrew D. Patterson,Andrew D. Patterson,Frank J. Gonzalez +10 more
TL;DR: A biochemical link between the microbiome, nuclear receptor signalling and metabolic disorders, and suggest that inhibition of FXR in the intestine could be a target for anti-obesity drugs are demonstrated.
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
Changtao Jiang,Changtao Jiang,Cen Xie,Fei Li,Limin Zhang,Robert G. Nichols,Kristopher W. Krausz,Jingwei Cai,Yunpeng Qi,Zhong-Ze Fang,Shogo Takahashi,Naoki Tanaka,Dhimant Desai,Shantu Amin,Istvan Albert,Andrew D. Patterson,Frank J. Gonzalez +16 more
TL;DR: It is demonstrated that inhibition of an intestinal FXR/ceramide axis mediates gut microbiota-associated NAFLD development, linking the microbiome, nuclear receptor signaling, andNAFLD.
Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota
Guolin Li,Guolin Li,Cen Xie,Siyu Lu,Robert G. Nichols,Yuan Tian,Licen Li,Daxeshkumar P. Patel,Yinyan Ma,Chad Brocker,Tingting Yan,Kristopher W. Krausz,Rong Xiang,Oksana Gavrilova,Andrew D. Patterson,Frank J. Gonzalez +15 more
TL;DR: It is shown that an every-other-day fasting (EODF) regimen selectively stimulates beige fat development within white adipose tissue and dramatically ameliorates obesity, insulin resistance, and hepatic steatosis.
559
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.
Changtao Jiang,Cen Xie,Ying Lv,Jing Li,Kristopher W. Krausz,Jingmin Shi,Chad Brocker,Dhimant Desai,Shantu Amin,William H. Bisson,Yulan Liu,Oksana Gavrilova,Andrew D. Patterson,Frank J. Gonzalez +13 more
TL;DR: Treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity, suggesting that Gly-M CA may be a candidate for the treatment of metabolic disorders.