Chuyu Yun
Peking University
19 Papers
1 Citations
Chuyu Yun is an academic researcher from Peking University. The author has contributed to research in topics: Internal medicine & Insulin resistance. The author has an hindex of 4, co-authored 9 publications.
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Papers
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.
Lulu Sun,Cen Xie,Guang Wang,Yue Wu,Qing Wu,Xuemei Wang,Jia Liu,Yangyang Deng,Jialin Xia,Bo Chen,Song-Yang Zhang,Chuyu Yun,Guan Lian,Xiujuan Zhang,Heng Zhang,William H. Bisson,Jingmin Shi,Xiaoxia Gao,Pupu Ge,Cui Hua Liu,Kristopher W. Krausz,Robert G. Nichols,Jingwei Cai,Bipin Rimal,Andrew D. Patterson,Xian Wang,Frank J. Gonzalez,Changtao Jiang +27 more
TL;DR: It is concluded that metformin acts in part through a B. fragilis–GUDCA–intestinal FXR axis to improve metabolic dysfunction, including hyperglycemia, and improves the metabolic health of humans and mice.
843
Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.
Xinyu Qi,Chuyu Yun,Lulu Sun,Jialin Xia,Qing Wu,Ying Wang,Lina Wang,Yangming Zhang,Xianyi Liang,Liying Wang,Frank J. Gonzalez,Andrew D. Patterson,Huiying Liu,Liangshan Mu,Zehong Zhou,Yue Zhao,Rong Li,Ping Liu,Chao Zhong,Yanli Pang,Changtao Jiang,Jie Qiao +21 more
TL;DR: It is suggested that modifying the gut microbiota, altering bile acid metabolism and/or increasing IL-22 levels may be of value for the treatment of PCOS, and glycodeoxycholic acid levels are consistent with the reduced levels of IL- 22 in individuals with PCOS.
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The impact of the gut microbiota on the reproductive and metabolic endocrine system
TL;DR: As the gut microbiota exerts various effects on the intestinal milieu which influences distant organs and pathways, it is considered to be a full-fledged endocrine organ as mentioned in this paper, and plays a major role in the development of human health.
303
Effects of Androgen Excess-Related Metabolic Disturbances on Granulosa Cell Function and Follicular Development
TL;DR: This study offers new insights into understanding the role of androgen excess induced granulosa cell metabolic disorder in ovarian dysfunction of PCOS patients and reveals close interactions among these three pathways as identified by analysis of the protein-protein interaction (PPI) network of DEGs.
97
Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis
Qing Wu,Lulu Sun,Xiaomin Hu,Xuemei Wang,Feng Xu,Bo Chen,Xianyi Liang,Jialin Xia,Pengcheng Wang,Daisuke Aibara,Shaofei Zhang,Guangyi Zeng,Chuyu Yun,Yu Yan,Yicheng Zhu,Michael Bustin,Shuyang Zhang,Frank J. Gonzalez,Changtao Jiang +18 more
TL;DR: In this article, the role of intestinal FXR in atherosclerosis and its potential as a target for clinical treatment have not been explored, but it is known that the serum levels of fibroblast growth factor 19 (FGF19), encoded by an FXR target gene, were much higher in patients with hypercholesterolemia than in control subjects and were positively related to circulating ceramide levels.