William Hageman
Johnson & Johnson Pharmaceutical Research and Development
12 Papers
108 Citations
William Hageman is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Receptor & Bioavailability. The author has an hindex of 10, co-authored 12 publications.
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Papers
Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?
TL;DR: It is shown, using a large diverse set of drugs, that a fixed exponent allometric scaling approach can be used to predict humanin-vivo PK parameters CL, Vss and t1/2 solely from rat data with acceptable accuracy for making go/no-go decisions in drug discovery.
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Synthesis and Biological Evaluation of Novel Pyridazinone-Based α4 Integrin Receptor Antagonists
Yong Gong,Barbay Jk,Alexey B. Dyatkin,Tamara A. Miskowski,Edward S. Kimball,Stephen M. Prouty,M. C. Fisher,Rosemary J. Santulli,Craig R. Schneider,N. H. Wallace,Scott A. Ballentine,William Hageman,John A. Masucci,Bruce E. Maryanoff,Bruce P. Damiano,Patricia Andrade-Gordon,Dennis J. Hlasta,Pamela J. Hornby,Wei He +18 more
TL;DR: The pharmacokinetic properties of selected members of the pyridazinone-functionalized phenylalanine analogues have been determined in rats and demonstrate that the use of ester prodrugs and alterations to the amide linkage can lead to improved oral bioavailability in this series.
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Synthesis and biological evaluation of novel indoloazepine derivatives as non-peptide vasopressin V2 receptor antagonists.
Matthews Jay M,Michael N. Greco,Leonard R. Hecker,William J. Hoekstra,Patricia Andrade-Gordon,Lawrence de Garavilla,Keith T. Demarest,Eric Ericson,Joseph W. Gunnet,William Hageman,Richard Look,John B. Moore,Bruce E. Maryanoff +12 more
TL;DR: A series of novel 3,4,5,6-tetrahydro-1H-azepino[4,3,2-cd]indoles was synthesized and tested for vasopressin receptor antagonist activity and identified compounds with high affinity for the human V2 receptor and good selectivity over the humanV1a receptor.
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The application of nuclear magnetic resonance-based metabonomics to the dominant-submissive rat behavioral model.
Gregory C. Leo,Gary W. Caldwell,Jeffrey Crooke,Ewa Malatynska,Carlos Cotto,Becki Hastings,Jaclyn Scowcroft,Jeffrey Hall,Karina Browne,William Hageman +9 more
TL;DR: Measurements of galactose showed that the amount present in the urine correlated with the time spent in the feeder zone, thereby supporting the time criterion established for the DSR model.
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Liquid chromatographic and tandem mass spectrometric assay for evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors: application of biomarkers in drug discovery
Wensheng Lang,John A. Masucci,Gary W. Caldwell,William Hageman,Jeffrey Hall,William J. Jones,Bryan M. Rafferty +6 more
TL;DR: The results indicated that 5-HIAA and PEA were susceptible and effective biomarkers in the rat brain in response to MAO A and B inhibition, respectively.
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