5 Papers
25 Citations
Wei He is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Receptor & Structure–activity relationship. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Wei He include Johnson & Johnson.
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Papers
Modulation of gastrointestinal function by MuDelta, a mixed µ opioid receptor agonist/ µ opioid receptor antagonist
Paul R. Wade,Jeffrey M. Palmer,S. McKenney,V Kenigs,Kristen M. Chevalier,BA Moore,John R. Mabus,P. R. Saunders,N. H. Wallace,Craig R. Schneider,Edward S. Kimball,Henry J. Breslin,Wei He,Pamela J. Hornby +13 more
TL;DR: This work tested whether modulating µ opioid receptor agonism with δ opioid receptor antagonism, by combining reference compounds or using a novel compound (‘MuDelta’), could normalize GI motility without constipation.
114
Synthesis and Biological Evaluation of Novel Pyridazinone-Based α4 Integrin Receptor Antagonists
Yong Gong,Barbay Jk,Alexey B. Dyatkin,Tamara A. Miskowski,Edward S. Kimball,Stephen M. Prouty,M. C. Fisher,Rosemary J. Santulli,Craig R. Schneider,N. H. Wallace,Scott A. Ballentine,William Hageman,John A. Masucci,Bruce E. Maryanoff,Bruce P. Damiano,Patricia Andrade-Gordon,Dennis J. Hlasta,Pamela J. Hornby,Wei He +18 more
TL;DR: The pharmacokinetic properties of selected members of the pyridazinone-functionalized phenylalanine analogues have been determined in rats and demonstrate that the use of ester prodrugs and alterations to the amide linkage can lead to improved oral bioavailability in this series.
39
Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists.
Yong Gong,J. Kent Barbay,Mieke Buntinx,Jian Li,Jean Pierre Frans Van Wauwe,Concha Claes,Guy Van Lommen,Pamela J. Hornby,Wei He +8 more
TL;DR: Primary anilines, in general, outperformed tertiary analogs in inhibition of C5a-induced calcium mobilization and the functional IC(50) of selected analogs was optimized to the single-digit nanomolar level.
18
Aza-bicyclic amino acid sulfonamides as α4β1/α4β7 integrin antagonists
Alexey B. Dyatkin,William J. Hoekstra,William A. Kinney,Maria Kontoyianni,Rosemary J. Santulli,Edward S. Kimball,M. Carolyn Fisher,Stephen M. Prouty,William M. Abraham,Patricia Andrade-Gordon,Dennis J. Hlasta,Wei He,Pamela J. Hornby,Bruce P. Damiano,Bruce E. Maryanoff +14 more
TL;DR: In this paper, the design, synthesis, and biological activity of novel α 4 β 1 and α 4β 7 integrin antagonists, containing a bridged azabicyclic nucleus, are reported.
9
Synthesis and characterization of 5,6,7,8-tetrahydroquinoline C5a receptor antagonists.
J. Kent Barbay,Yong Gong,Mieke Buntinx,Jian Li,Concha Claes,Pamela J. Hornby,Guy Van Lommen,Jean Pierre Frans Van Wauwe,Wei He +8 more
TL;DR: A novel series of substituted 2-aryl-5-amino-5,6,7,8-tetrahydroquinoline C5a receptor antagonists is reported, which display high binding affinity for the C 5a receptor and are potent functional antagonists.