Michael N. Greco
Wilmington University
38 Papers
321 Citations
Michael N. Greco is an academic researcher from Wilmington University. The author has contributed to research in topics: Proteases & Serine. The author has an hindex of 14, co-authored 38 publications. Previous affiliations of Michael N. Greco include Johnson & Johnson Pharmaceutical Research and Development.
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Papers
A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase MOLECULAR MECHANISMS AND ANTI-INFLAMMATORY ACTIVITY IN VIVO
Lawrence de Garavilla,Michael N. Greco,Narayanasami Sukumar,Zhi-wei Chen,Agustin O. Pineda,F. Scott Mathews,Enrico Di Cera,Edward C. Giardino,Grace I. Wells,Barbara J. Haertlein,Jack A. Kauffman,Thomas W. Corcoran,Claudia K. Derian,Annette J. Eckardt,Bruce P. Damiano,Patricia Andrade-Gordon,Bruce E. Maryanoff +16 more
TL;DR: It is demonstrated that it is possible to inhibit both cathepsin G and chymase with a single molecule and suggest an exciting opportunity in the treatment of asthma and chronic obstructive pulmonary disease.
97
Macrocyclic Peptide Inhibitors of Serine Proteases. Convergent Total Synthesis of Cyclotheonamides A and B via a Late-Stage Primary Amine Intermediate. Study of Thrombin Inhibition under Diverse Conditions
Bruce E. Maryanoff,Michael N. Greco,Han-Cheng Zhang,Patricia Andrade-Gordon,Jack A. Kauffman,Kyriacos C. Nicolaou,Aijun Liu,Peter H. Brungs +7 more
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Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.
Michael N. Greco,Michael J. Hawkins,Powell Eugene,Harold R. Almond,Lawrence de Garavilla,Jeffrey Hall,Lisa Minor,Yuanping Wang,Thomas W. Corcoran,Enrico Di Cera,Angelene M. Cantwell,Savvas N. Savvides,Bruce P. Damiano,Bruce E. Maryanoff +13 more
TL;DR: A series of beta-carboxamido-phosphon(in)ic acids was identified as a new structural motif for obtaining potent inhibitors of human mast cell chymase and revealed key interactions within the enzyme active site.
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Nonpeptide inhibitors of cathepsin G: optimization of a novel beta-ketophosphonic acid lead by structure-based drug design.
Michael N. Greco,Michael J. Hawkins,Powell Eugene,Harold R. Almond,Thomas W. Corcoran,Lawrence de Garavilla,Jack A. Kauffman,Rosario Recacha,Debashish Chattopadhyay,Patricia Andrade-Gordon,Bruce E. Maryanoff +10 more
TL;DR: It is evident that the beta-ketophosphonic acid unit can form the basis for a novel class of serine protease inhibitors.
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Solid-phase synthesis via N-terminal attachment to the 2-chlorotrityl resin
TL;DR: In this paper, the connection of a secondary amine to the 2-chlorotrityl resin followed by iterative saponification/coupling sequences provided a basis for generating focused peptidomimetic mini-libraries.
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