Shinji Negoro
Osaka University
21 Papers
499 Citations
Shinji Negoro is an academic researcher from Osaka University. The author has contributed to research in topics: STAT3 & Glycoprotein 130. The author has an hindex of 17, co-authored 21 publications.
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Papers
Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy.
Keita Kunisada,Shinji Negoro,Eiroh Tone,Masanobu Funamoto,Tomoaki Osugi,Shuichi Yamada,Masaru Okabe,Tadamitsu Kishimoto,Keiko Yamauchi-Takihara +8 more
TL;DR: Results provide direct evidence that STAT3 transduces not only a hypertrophic signal but also a protective signal against Dox-induced cardiomyopathy by inhibiting reduction of cardiac contractile genes and inducing cardiac protective factors.
295
Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction.
Shinji Negoro,Keita Kunisada,Eiroh Tone,Masanobu Funamoto,Hidemasa Oh,Tadamitsu Kishimoto,Keiko Yamauchi-Takihara +6 more
TL;DR: The JAK/STAT pathway is activated in AMI myocardium and plays a pivotal role in cytoprotective signaling.
241
Alternation in the Coronary Blood Flow Velocity Pattern in Patients With No Reflow and Reperfused Acute Myocardial Infarction
Katsuomi Iwakura,Hiroshi Ito,Shin Takiuchi,Yoshiaki Taniyama,Yoshiaki Nakatsuchi,Shinji Negoro,Yorihiko Higashino,Atsunori Okamura,Tohru Masuyama,Masatsugu Hori,Kenshi Fujii,Takazo Minamino +11 more
TL;DR: The coronary flow velocity pattern in patients with the no-reflow phenomenon was characterized by the appearance of systolic retrograde flow, diminished syStolic antegrades flow, and rapid deceleration of diastolic flow.
241
Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes.
Masanobu Funamoto,Yasushi Fujio,Yasushi Fujio,Keita Kunisada,Shinji Negoro,Eiroh Tone,Tomoaki Osugi,Hisao Hirota,Masahiro Izumi,Kazuyuki Yoshizaki,Kenneth Walsh,Tadamitsu Kishimoto,Keiko Yamauchi-Takihara +12 more
TL;DR: Data provide the first evidence that a STAT family protein functions as a regulator of angiogenic growth factors and suggest that gp130/STAT signaling in cardiac myocytes can control vessel growth during cardiac remodeling.
163
Cardiac-specific Activation of Signal Transducer and Activator of Transcription 3 Promotes Vascular Formation in the Heart
Tomoaki Osugi,Yuichi Oshima,Yasushi Fujio,Masanobu Funamoto,Atsuko Yamashita,Shinji Negoro,Keita Kunisada,Masahiro Izumi,Yoshikazu Nakaoka,Hisao Hirota,Masaru Okabe,Keiko Yamauchi-Takihara,Ichiro Kawase,Tadamitsu Kishimoto +13 more
TL;DR: The study presented here provides the first evidence that activation of STAT3 controls vessel growth in vivo and suggests that STAT3 contributes to cardiac adaptation by regulating vascular function under the conditions of stress.
159