Yuichi Oshima
Osaka University
22 Papers
366 Citations
Yuichi Oshima is an academic researcher from Osaka University. The author has contributed to research in topics: Myocyte & Glycoprotein 130. The author has an hindex of 14, co-authored 22 publications.
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Papers
Cardiac-specific Activation of Signal Transducer and Activator of Transcription 3 Promotes Vascular Formation in the Heart
Tomoaki Osugi,Yuichi Oshima,Yasushi Fujio,Masanobu Funamoto,Atsuko Yamashita,Shinji Negoro,Keita Kunisada,Masahiro Izumi,Yoshikazu Nakaoka,Hisao Hirota,Masaru Okabe,Keiko Yamauchi-Takihara,Ichiro Kawase,Tadamitsu Kishimoto +13 more
TL;DR: The study presented here provides the first evidence that activation of STAT3 controls vessel growth in vivo and suggests that STAT3 contributes to cardiac adaptation by regulating vascular function under the conditions of stress.
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Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway.
Masahiro Izumi,Yasushi Fujio,Keita Kunisada,Shinji Negoro,Eiro Tone,Masanobu Funamoto,Tomoaki Osugi,Yuichi Oshima,Yoshikazu Nakaoka,Tadamitsu Kishimoto,Keiko Yamauchi-Takihara,Hisao Hirota +11 more
TL;DR: The findings suggest that BMP-2 prevents apoptosis of myocytes by induction of Bcl-xLvia a Smad1 pathway and might be a novel survival factor without any hypertrophic effect on myocytes.
105
Activation of gp130 Transduces Hypertrophic Signal Through Interaction of Scaffolding/Docking Protein Gab1 With Tyrosine Phosphatase SHP2 in Cardiomyocytes
Yoshikazu Nakaoka,Keigo Nishida,Yasushi Fujio,Masahiro Izumi,Kazuo Terai,Yuichi Oshima,Shoko Sugiyama,Satoshi Matsuda,Shigeo Koyasu,Keiko Yamauchi-Takihara,Toshio Hirano,Ichiro Kawase,Hisao Hirota +12 more
TL;DR: The findings indicate that Gab1-SHP2 interaction plays a crucial role in gp130-dependent longitudinal elongation of cardiomyoctes through activation of ERK5.
95
Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure
Hisao Hirota,Masahiro Izumi,Tomoyuki Hamaguchi,Shoko Sugiyama,Eiki Murakami,Keita Kunisada,Yasushi Fujio,Yuichi Oshima,Yoshikazu Nakaoka,Keiko Yamauchi-Takihara +9 more
TL;DR: The findings suggest that gp130 expression in the heart is likely to be dynamic, and that the IL-6 family of cytokines and their common receptor gp130 participates in the pathogenesis of CHF, especially in DCM.
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Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes.
Yasushi Fujio,Takahisa Matsuda,Yuichi Oshima,Makiko Maeda,Tomomi Mohri,Takashi Ito,Tomoka Takatani,Mayo Hirata,Yoshikazu Nakaoka,Ryusuke Kimura,Tadamitsu Kishimoto,Junichi Azuma +11 more
TL;DR: It is demonstrated that the stimulation of gp130 with leukemia inhibitory factor (LIF) promoted cell adhesion in a cadherin‐dependent manner in cultured cardiomyocytes.
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