Kenneth Walsh
University of Virginia
545 Papers
7.6K Citations
Kenneth Walsh is an academic researcher from University of Virginia. The author has contributed to research in topics: Protein kinase B & Biology. The author has an hindex of 123, co-authored 528 publications. Previous affiliations of Kenneth Walsh include University of Utah & Case Western Reserve University.
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Papers
Adipokines in inflammation and metabolic disease
TL;DR: The role of adipokines in inflammatory responses is focused on and their potential as regulators of metabolic function is discussed.
Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy
Marco Sandri,Claudia Sandri,Alexander Gilbert,Carsten Skurk,Elisa Calabria,Anne Picard,Kenneth Walsh,Stefano Schiaffino,Stewart H. Lecker,Alfred L. Goldberg +9 more
TL;DR: It is shown that in cultured myotubes undergoing atrophy, the activity of the PI3K/AKT pathway decreases, leading to activation of Foxo transcription factors and atrogin-1 induction.
2.9K
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt.
David Fulton,Jean-Philippe Gratton,Timothy J. McCabe,Jason Fontana,Yasushl Fujio,Kenneth Walsh,Thomas F. Franke,Andreas Papapetropoulos,William C. Sessa +8 more
TL;DR: It is shown that the serine/threonine protein kinase Akt (protein kinase B) can directly phosphorylate eNOS on serine 1179 and activate the enzyme, leading to NO production, whereas mutant eN OS (S1179A) is resistant to phosphorylation and activation by Akt.
2.7K
The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.
Yasuko Kureishi,Zhengyu Luo,Ichiro Shiojima,Ann Bialik,David Fulton,David J. Lefer,William C. Sessa,Kenneth Walsh +7 more
TL;DR: Simvastatin enhanced phosphorylation of the endogenous Akt substrate endothelial nitric oxide synthase, inhibited apoptosis and accelerated vascular structure formation in vitro in an Akt-dependent manner, and promoted angiogenesis in ischemic limbs of normocholesterolemic rabbits.
1.4K
Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice
José J. Fuster,Susan MacLauchlan,María A. Zuriaga,Maya N. Polackal,Allison C. Ostriker,Raja Chakraborty,Chia-Ling Wu,Soichi Sano,Sujatha Muralidharan,Cristina Rius,Jacqueline T Vuong,Sophia Jacob,Varsha Muralidhar,Avril A. B. Robertson,Mark E. Cooper,Vicente Andrés,Karen K. Hirschi,Kathleen A. Martin,Kenneth Walsh +18 more
TL;DR: The effects of the expansion of Tet2-mutant cells in atherosclerosis-prone, low-density lipoprotein receptor–deficient mice are studied and it is found that partial bone marrow reconstitution with TET2-deficient cells was sufficient for their clonal expansion and led to a marked increase in Atherosclerotic plaque size.