Huan Chen
Shanghai Jiao Tong University
10 Papers
Huan Chen is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 2, co-authored 4 publications. Previous affiliations of Huan Chen include Shanghai University.
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Papers
ADSCs-derived extracellular vesicles alleviate neuronal damage, promote neurogenesis and rescue memory loss in mice with Alzheimer's disease.
Xinyi Ma,Meng Huang,Mengna Zheng,Chengxiang Dai,Qingxiang Song,Qian Zhang,Qian Li,Xiao Gu,Huan Chen,Gan Jiang,Ye Yu,Xuesong Liu,Suke Li,Gang Wang,Hong-Zhuan Chen,Liangjing Lu,Xiaoling Gao +16 more
TL;DR: In this paper, extracellular vesicles secreted from adipose-derived mesenchymal stem cells (ADSCs-derived EVs, abbreviated as EVs) entered the brain quickly and efficiently following intranasal administration, and majorly accumulated in neurons within the central nervous system.
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Tailored Lipoprotein-Like miRNA Delivery Nanostructure Suppresses Glioma Stemness and Drug Resistance through Receptor-Stimulated Macropinocytosis
Gan Jiang,Huan Chen,Huan Chen,Jialin Huang,Qingxiang Song,Yaoxing Chen,Xiao Gu,Zhenhuan Jiang,Yukun Huang,Yingying Lin,Junfeng Feng,Jiyao Jiang,Ying-hui Bao,Gang Zheng,Jun Chen,Hong-Zhuan Chen,Hong-Zhuan Chen,Xiaoling Gao +17 more
TL;DR: A tailored lipoprotein‐based nanostructure realizes efficient GICs accumulation and therapeutic effect through receptor‐stimulated macropinocytosis, providing a powerful nanoplatform for RNA interference drugs to combat glioma.
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CaP-based anti-inflammatory HIF-1α siRNA-encapsulating nanoparticle for rheumatoid arthritis therapy.
Xue-Song Liu,Ruru Guo,Shicheng Huo,Huan Chen,Qingxiang Song,Gan Jiang,Ye Yu,Jialin Huang,Shaowei Xie,Xiaoling Gao,Liangjing Lu +10 more
TL;DR: Wang et al. as mentioned in this paper proposed HIF-1α siRNA-loaded calcium phosphate nanoparticles encapsulated in apolipoprotein E3-reconstituted high-density lipoprotein (HIF-CaP-rHDL) for RA therapy.
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Self-Disassembling and Oxygen-Generating Porphyrin-Lipoprotein Nanoparticle for Targeted Glioblastoma Resection and Enhanced Photodynamic Therapy.
Yaoxing Chen,Yuxiao Ma,Kexin Shi,Huan Chen,Xiao Han,Chen-Xuan Wei,Yingqi Lyu,Yukun Huang,Renhe Yu,Yun Song,Qingxiang Song,Jiyao Jiang,Junfeng Feng,Yingying Lin,Jun Chen,Hongzhuan Chen,Gang Zheng,Xiaoling Gao,Gan Jiang +18 more
TL;DR: Self-disassembling and oxygen-generating porphyrin-lipoprotein nanoparticle for targeted glioblastoma resection and enhanced photodynamic therapy enhances PDT efficacy and alleviates hypoxia.
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Multifunctional Nanostructure RAP-RL Rescues Alzheimer's Cognitive Deficits through Remodeling the Neurovascular Unit.
Qian Zhang,Qingxiang Song,Xiao Gu,Mengna Zheng,Antian Wang,Gan Jiang,Meng Huang,Huan Chen,Yu Qiu,Bin Bo,Shanbao Tong,Rong Shao,Binyin Li,Gang Wang,Hao Wang,Yong-Bo Hu,Hong-Zhuan Chen,Hong-Zhuan Chen,Xiaoling Gao +18 more
TL;DR: The proof of concept that remodeling the functional NVU may represent a promising therapeutic approach toward effective intervention of AD is provided and the potential of the multifunctional nanostructure RAP‐RL as a disease‐modifying modality for AD treatment is demonstrated.
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