Gan Jiang
Shanghai Jiao Tong University
34 Papers
13 Citations
Gan Jiang is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Medicine & Drug delivery. The author has an hindex of 9, co-authored 18 publications.
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Papers
Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras -activated glioblastoma cells via macropinocytosis
Jialin Huang,Gan Jiang,Qingxiang Song,Xiao Gu,Meng Hu,Xiaolin Wang,Huahua Song,Lepei Chen,Yingying Lin,Di Jiang,Jun Chen,Junfeng Feng,Yongming Qiu,Jiyao Jiang,Xinguo Jiang,Hong-Zhuan Chen,Xiaoling Gao +16 more
TL;DR: A biologically inspired nanostructure that can induce cancer cells to ‘drink drugs' for targeting activating transcription factor-5 (ATF5), an overexpressed anti-apoptotic transcription factor in glioblastoma and other Ras-activated cancers is created.
ADSCs-derived extracellular vesicles alleviate neuronal damage, promote neurogenesis and rescue memory loss in mice with Alzheimer's disease.
Xinyi Ma,Meng Huang,Mengna Zheng,Chengxiang Dai,Qingxiang Song,Qian Zhang,Qian Li,Xiao Gu,Huan Chen,Gan Jiang,Ye Yu,Xuesong Liu,Suke Li,Gang Wang,Hong-Zhuan Chen,Liangjing Lu,Xiaoling Gao +16 more
TL;DR: In this paper, extracellular vesicles secreted from adipose-derived mesenchymal stem cells (ADSCs-derived EVs, abbreviated as EVs) entered the brain quickly and efficiently following intranasal administration, and majorly accumulated in neurons within the central nervous system.
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Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors.
Yukun Huang,Yu Chen,Songlei Zhou,Liang Chen,Jiahao Wang,Yuanyuan Pei,Minjun Xu,Jingxian Feng,Tianze Jiang,Kaifan Liang,Shanshan Liu,Qingxiang Song,Gan Jiang,Xiao Gu,Qian Zhang,Xiaoling Gao,Jun Chen +16 more
TL;DR: A dual-mechanism based CTLs infiltration enhancer, Nano-sapper, is reported, which can simultaneously reduce the physical obstacles in tumor microenvironment and recruiting C TLs to potentiate immunotherapy in IET.
Necroptotic cancer cells-mimicry nanovaccine boosts anti-tumor immunity with tailored immune-stimulatory modality.
Ting Kang,Yukun Huang,Qianqian Zhu,Hao Cheng,Yuanyuan Pei,Jingxian Feng,Minjun Xu,Gan Jiang,Qingxiang Song,Tianze Jiang,Hong-Zhuan Chen,Xiaoling Gao,Jun Chen +12 more
TL;DR: Proof-of-concept evidence is demonstrated for the feasibility, capability and safety of a nanovaccine platform towards efficient personalized anticancer application and αHSP70p-CM-CaP vaccination led to the killing of target cells and tumor regression in vivo when combined with anti-PD-1 antibody treatment on mice B16OVA melanoma models.
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Engineering ApoE3-incorporated biomimetic nanoparticle for efficient vaccine delivery to dendritic cells via macropinocytosis to enhance cancer immunotherapy
Songlei Zhou,Yukun Huang,Yu Chen,Shanshan Liu,Minjun Xu,Tianze Jiang,Qingxiang Song,Gan Jiang,Xiao Gu,Xiaoling Gao,Jun Chen +10 more
TL;DR: It is demonstrated that by utilizing the macropinocytosis pathway, ApoE3-incorporated biomimetic nanoparticle has great potential to function as a feasible, effective, and safe nanovaccine for cancer immunotherapy.
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