Hannah G. Polikowsky
Vanderbilt University Medical Center
27 Papers
52 Citations
Hannah G. Polikowsky is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 6, co-authored 14 publications. Previous affiliations of Hannah G. Polikowsky include Vanderbilt University.
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Papers
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
Ken Suzuki,Konstantinos Hatzikotoulas,L. Southam,Henry J. Taylor,Xianyong Yin,Kim M Lorenz,Ravi Mandla,Alicia Huerta-Chagoya,Giorgio E M Melloni,Stavroula Kanoni,Nigel W. Rayner,Ozvan Bocher,A. L. Arruda,Kyuto Sonehara,Shinichi Namba,Simon S K Lee,Michael Preuss,Lauren E. Petty,Philip H. Schroeder,Brett R. Vanderwerff,Mart Kals,Fiona Bragg,Kuang Lin,Xiuqing Guo,Weihua Zhang,Jie Yao,Young Jin Kim,Mariaelisa Graff,Fumihiko Takeuchi,Jana Nano,Amel Lamri,Masahiro Nakatochi,Sanghoon Moon,Robert A. Scott,James P. Cook,Jung-Jin Lee,Ian Pan,Daniel Taliun,Esteban J. Parra,Jin-Fang Chai,Lawrence F. Bielak,Yasuharu Tabara,Yang Hai,Gudmar Thorleifsson,Niels Grarup,Tamar Sofer,Matthias Wuttke,Chloé Sarnowski,Christian Gieger,Darryl Nousome,Stella Trompet,Soo Heon Kwak,Jirong Long,Meng Die Sun,Lin Tong,Wei-Min Chen,Suraj S. Nongmaithem,Raymond Noordam,V. J. Lim,Claudia H. T. Tam,Yoonjung Yoonie Joo,Chien-Hsiun Chen,Laura M. Raffield,Bram P. Prins,Aude Nicolas,Lisa R. Yanek,Guanjie Chen,Jennifer A. Brody,Edmond K Kabagambe,Ping An,Anny H. Xiang,Hyeok Sun Choi,Brian E. Cade,Jingyi Tan,K. Alaine Broadaway,Alice E. Williamson,Zoha Kamali,Jinrui Cui,Manonanthini Thangam,Linda S. Adair,Adebowale Adeyemo,C. A. Aguilar-Salinas,Tarunveer S. Ahluwalia,S. Anand,Alain G. Bertoni,Jette Bork-Jensen,Ivan Brandslund,Thomas A. Buchanan,Charles F. Burant,Adam S. Butterworth,Mickaël Canouil,Juliana C N Chan,Li Chang,Miao Li Chee,Ji Chen,Shyh-Huei Chen,Yuan-Tsong Chen,Zhengmin Chen,Lee-Ming Chuang,Mary Cushman,John Danesh,Swapan K Das,H. D. de Silva,George Dedoussis,Latchezar Dimitrov,Ayo P. Doumatey,Shufa Du,Qing Duan,K.-U. Eckardt,Leslie S. Emery,Daniel S. Evans,Michele K. Evans,K. Fischer,James S. Floyd,Ian Ford,Oscar H Franco,Timothy M. Frayling,Barry I. Freedman,Pauline Genter,Hertzel C. Gerstein,Vilmantas Giedraitis,Clicerio González-Villalpando,María Elena González-Villalpando,Penny Gordon-Larsen,Myron Gross,L. Guare,Sophie Hackinger,Liisa Hakaste,Sohee Han,Andrew T Hattersley,Christian Herder,Momoko Horikoshi,Annie Green Howard,Willa A. Hsueh,Mengna Huang,Wei Huang,Yi Jen Hung,Mi Yeong Hwang,Chii-Min Hwu,Sahoko Ichihara,M. A. Ikram,Martin Ingelsson,Md. Tariqul Islam,Masato Isono,Hye-Mi Jang,Farzana Jasmine,Guozhi Jiang,Jost B. Jonas,Torben Jørgensen,Frederick K. Kamanu,Fouad R. Kandeel,Anuradhani Kasturiratne,Tomohiro Katsuya,Varinderpal Kaur,Takahisa Kawaguchi,Jacob M. Keaton,Abel N. Kho,Chiea Chuen Khor,Muhammad G. Kibriya,Duk-Hwan Kim,Florian Kronenberg,Johanna Kuusisto,Kristi Läll,Leslie A. Lange,Myung M. Lee,Myung Shik Lee,Nanette R. Lee,Aaron Leong,Liming Li,Yun Li,Ruifang Li-Gao,Symen Ligthart,Cecilia M. Lindgren,A. Linneberg,Ching-Ti Liu,Jianjun Liu,Adam E. Locke,Tin Louie,Jian'an Luan,Andrea O.Y. Luk,Xi Luo,Jun Lv,Julie A. Lynch,Valeriya Lyssenko,Shiro Maeda,Vasiliki Mamakou,Sohail R. Mansuri,Koichi Matsuda,Thomas Meitinger,Olle Melander,Andres Metspalu,Huan Mo,Andrew D. Morris,Filipe A Moura,Jerry L. Nadler,Michael A. Nalls,Uma Nayak,Ioanna Ntalla,Yukinori Okada,Lorena Orozco,Sanjay R Patel,Snehal Patil,P. Pei,Mark A Pereira,A. Peters,Fraser J. Pirie,Hannah G. Polikowsky,Bianca Porneala,Gauri Prasad,Laura J. Rasmussen-Torvik,Alexander P Reiner,Michael Roden,Rebecca Rohde,Kathryn Roll,Charumathi Sabanayagam,Kevin Sandow,Alagu Sankareswaran,Naveed Sattar,Sebastian Schönherr,Mohammad Hasan Shahriar,Botong Shen,Jinxiu Shi,Dong Mun Shin,Nobuhiro Shojima,Jennifer A. Smith,Wing-Yee So,Alena Stančáková,Valgerdur Steinthorsdottir,Adrienne M. Stilp,Konstantin Strauch,Kent D. Taylor,Barbara Thorand,Unnur Thorsteinsdottir,Brian Tomlinson,Fuu-Jen Tsai,Jaakko Tuomilehto,Teresa Tusié-Luna,Miriam S. Udler,Adan Valladares-Salgado,Rob M. van Dam,Jan B. van Klinken,Rohit Varma,Niels Wacher-Rodarte,Eleanor Wheeler,Ananda R. Wickremasinghe,Ko Willems van Dijk,Daniel Witte,Chittaranjan S. Yajnik,Kenichi Yamamoto,Kenichi Yamamoto,Kyungheon Yoon,Canqing Yu,Jian-Min Yuan,Salim Yusuf,Matthew Zawistowski,Xiang Zhang,Wei-Hui Zheng,Leslie J. Raffel,Michiya Igase,Eli Ipp,S. Redline,Yoon Shin Cho,Lars Lind,Michael A. Province,Myriam Fornage,Craig L. Hanis,Erik Ingelsson,Alan B. Zonderman,B. Psaty,Ya-Xing Wang,Charles N. Rotimi,Diane Becker,Fumihiko Matsuda,Yongmei Liu,Mitsuhiro Yokota,Sharon L.R. Kardia,Patricia A. Peyser,James S. Pankow,James C. Engert,Amélie Bonnefond,P. Froguel,James G Wilson,W. H. Sheu,Jer-Yuarn Wu,M. G. Hayes,Ronald C W Ma,Tien Y. Wong,Dennis O. Mook-Kanamori,Tiinamaija Tuomi,Giriraj R. Chandak,Francis S. Collins,Dwaipayan Bharadwaj,Guillaume Paré,Michèle M. Sale,Habibul Ahsan,Ayesha A. Motala,Xiao-Ou Shu,K. Park,J. Jukema,Miguel Cruz,Yii-DerIda Chen,Stephen S. Rich,Roberta McKean-Cowdin,Harald Grallert,Ching-Yu Cheng,Mohsen Ghanbari,E. Shyong Tai,Jose C Dupuis,Norihiro Kato,Markku Laakso,A. Köttgen,Woon-Puay Koh,Donald W. Bowden,C. N. Palmer,Jaspal S. Kooner,Charles Kooperberg,Simin Liu,Kari E North,Danish Saleheen,Torben Hansen,Oluf Pedersen,N. Wareham,Juyoung Lee,Bong-Jo Kim,Iona Y. Millwood,Robin G. Walters,Kári Stefánsson,Emma Ahlqvist,Mark O. Goodarzi,Karen L. Mohlke,Claudia Langenberg,Christopher A. Haiman,Ruth J F Loos,J. C. Florez,Daniel J. Rader,Marylyn D. Ritchie,Sebastian Zöllner,Reedik Mägi,N. Marston,Christian T. Ruff,David A. van Heel,Sarah Finer,Joshua C Denny,Toshimasa Yamauchi,Takashi Kadowaki,John C Chambers,Maggie C.Y. Ng,Xueling Sim,Jennifer E. Below,Philip S. Tsao,Kyong-Mi Chang,M. McCarthy,James B. Meigs,Anubha Mahajan,Cassandra N. Spracklen,Josep M. Mercader,Michael Boehnke,Jerome I. Rotter,Marijana Vujkovic,Benjamin F. Voight,Andrew P Morris,Eleftheria Zeggini +361 more
TL;DR: The findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D.
129
Morphological profiling using machine learning reveals emergent subpopulations of interferon-γ-stimulated mesenchymal stromal cells that predict immunosuppression
Ross A. Marklein,Ross A. Marklein,Matthew W. Klinker,Katherine A. Drake,Hannah G. Polikowsky,Elizabeth C. Lessey-Morillon,Steven R. Bauer +6 more
TL;DR: This work provides a generalizable analytical platform for assessing functional heterogeneity based on single-cell morphological responses that could be used to identify novel CQAs and inform cell manufacturing decisions.
73
Bone Morphogenetic Proteins Stimulate Mammary Fibroblasts to Promote Mammary Carcinoma Cell Invasion
Philip Owens,Hannah G. Polikowsky,Michael W. Pickup,Agnieszka E. Gorska,Bojana Jovanovic,Aubie K. Shaw,Sergey V. Novitskiy,Charles C. Hong,Charles C. Hong,Harold L. Moses +9 more
TL;DR: It is demonstrated that BMP may stimulate tumor progression within the tumor microenvironment by elevating pro-tumorigenic secreted factors such as IL-6 and MMP-3.
High-Dimensional Analysis of Acute Myeloid Leukemia Reveals Phenotypic Changes in Persistent Cells during Induction Therapy
Paul Brent Ferrell,Kirsten E. Diggins,Hannah G. Polikowsky,Sanjay R. Mohan,Adam C. Seegmiller,Jonathan M. Irish,Jonathan M. Irish +6 more
TL;DR: In this paper, the authors conducted a pilot study of high dimensional longitudinal monitoring of immunophenotype in AML, using a 27-antibody panel for mass cytometry focused on surface diagnostic markers and applied it to 46 samples of blood or bone marrow tissue collected over time from 5 AML patients.
Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells
Hannah G. Polikowsky,Cara E. Wogsland,Kirsten E. Diggins,Kanutte Huse,Kanutte Huse,Jonathan M. Irish +5 more
TL;DR: It is shown that stage-specific redox responses distinguish human GC B cells, and BCR signaling responses in mature human tonsillar B cells undergoing germinal center (GC) reactions were hypersensitive to a range of H2O2 concentrations.