Sergey V. Novitskiy
Vanderbilt University Medical Center
61 Papers
132 Citations
Sergey V. Novitskiy is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Tumor microenvironment & Adenosine. The author has an hindex of 28, co-authored 55 publications. Previous affiliations of Sergey V. Novitskiy include Vanderbilt University & University of Texas MD Anderson Cancer Center.
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Papers
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
Berna C. Özdemir,Berna C. Özdemir,Tsvetelina Pentcheva-Hoang,Julienne L. Carstens,Xiaofeng Zheng,Chia Chin Wu,Tyler R. Simpson,Hanane Laklai,Hikaru Sugimoto,Hikaru Sugimoto,Christoph Kahlert,Christoph Kahlert,Sergey V. Novitskiy,Ana De Jesus-Acosta,Padmanee Sharma,Pedram Heidari,Umar Mahmood,Lynda Chin,Harold L. Moses,Valerie M. Weaver,Anirban Maitra,James P. Allison,Valerie S. LeBleu,Valerie S. LeBleu,Raghu Kalluri,Raghu Kalluri +25 more
TL;DR: Although myofibroblast-depleted tumors did not respond to gemcitabine, anti-CTLA4 immunotherapy reversed disease acceleration and prolonged animal survival, and underscores the need for caution in targeting carcinoma-associated fibroblasts in PDAC.
2.2K
Erratum to Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival [Cancer Cell 25, 719-734; (2014)]
Berna C. Özdemir,Tsvetelina Pentcheva-Hoang,Julienne L. Carstens,Xiaofeng Zheng,Chia Chin Wu,Tyler R. Simpson,Hanane Laklai,Hikaru Sugimoto,Christoph Kahlert,Sergey V. Novitskiy,Ana De Jesus-Acosta,Padmanee Sharma,Pedram Heidari,Umar Mahmood,Lynda Chin,Harold L. Moses,Valerie M. Weaver,Anirban Maitra,James P. Allison,Valerie S. LeBleu,Raghu Kalluri +20 more
TL;DR: This research highlights the need to understand more fully the role of language in the development of post-traumatic stress disorder and the role that language can play in the recovery.
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The roles of TGFβ in the tumour microenvironment
TL;DR: The role of an essential signalling pathway, that of transforming growth factor-β, in the regulation of components of the tumour microenvironment and how this contributes to tumour progression is addressed.
879
Lipid accumulation and dendritic cell dysfunction in cancer
Donna L. Herber,Wei Cao,Yulia Nefedova,Sergey V. Novitskiy,Srinivas Nagaraj,Vladimir A. Tyurin,Alex Corzo,Hyun Ii Cho,Esteban Celis,Brianna Lennox,Stella C. Knight,Tapan A. Padhya,Thomas V. McCaffrey,Judith C. McCaffrey,Scott J. Antonia,Mayer Fishman,Robert L. Ferris,Valerian E. Kagan,Dmitry I. Gabrilovich +18 more
TL;DR: In this article, a substantial proportion of Dendritic cells (DCs) in tumor-bearing mice and people with cancer have high amounts of triglycerides as compared with DCs from tumor-free mice and healthy individuals.
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
Hanane Laklai,Yekaterina A. Miroshnikova,Michael W. Pickup,Eric A. Collisson,Grace E. Kim,Alexander S. Barrett,Ryan C. Hill,Johnathon N. Lakins,David D. Schlaepfer,Janna K. Mouw,Valerie S. LeBleu,Nilotpal Roy,Sergey V. Novitskiy,Julia S. Johansen,Valeria Poli,Raghu Kalluri,Christine A. Iacobuzio-Donahue,Laura D. Wood,Matthias Hebrok,Kirk C. Hansen,Harold L. Moses,Valerie M. Weaver +21 more
TL;DR: The findings implicate epithelial tension and matricellular fibrosis in the aggressiveness of SMAD4 mutant pancreatic tumors and highlight STAT3 and mechanics as key drivers of this phenotype.