The Interaction Between Redox and Hypoxic Signalling Pathways in the Dynamic Oxygen Environment of Cancer Cells
TL;DR: The oxygen state of a tissue results fr om the relative contributions of oxygen consumption and delivery, depending on the location and function of the cells in an organ.
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Abstract: Oxygen is essential for the survival of all living beings. A balanced oxygen environment is required since both lower and higher than the required oxygen levels can be detrimental to the cells (Figure 1). The oxygen state of a tissue results fr om the relative contributions of oxygen consumption and delivery. Different organs in the body exist under different oxygen environments, depending on the location and function of the cells in an organ. Most healthy organs reside in 3-6% oxygen [1] while conditions lower than 3% oxygen are described as hypoxia. Cells also survive in hypoxic environments during normal development [2]. However, hypoxia is mostly detrimental to the cells by disrupting the oxygen homeostasis.
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Citations
Hypoxia-Modified Cancer Cell Metabolism.
Wafaa Al Tameemi,Tina P. Dale,Rakad M. Kh. Al-Jumaily,Rakad M. Kh. Al-Jumaily,Nicholas R. Forsyth +4 more
TL;DR: This review defines the current knowledge base of several of theHypoxia-instigated modifications in cancer cell metabolism and exemplifies the correlation between metabolic change and its support of the hypoxic-adapted malignancy.
Cross Talk Between Two Antioxidant Systems, Thioredoxin and DJ-1: Consequences for Cancer
Prahlad V. Raninga,Giovanna Di Trapani,Kathryn F. Tonissen +2 more
- 02 Jan 2014
TL;DR: This review focuses on the cross-talk between thioredoxin and DJ-1 and highlights the importance and consequences of targeting thiOREDoxin andDJ-1 together to develop an effective anti-cancer therapeutic strategy.
Effects of light intensity on phototaxis, growth, antioxidant and stress of juvenile gibel carp (Carassius auratus gibelio)
Hui Wei,Han-Dong Li,Yu Xia,Haokun Liu,Dong Han,Xiaoming Zhu,Yunxia Yang,Junyan Jin,Shouqi Xie +8 more
TL;DR: The results showed that the best growth of juvenile gibel carp were observed at 0.03–1.08 μmol·m−2·s−1, and based on the quadratic regression analysis of specific growth rate, the optimal light intensity for juvenilegibel carp was 0.39’s mol·m-2-s-1.
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Phytochemical studies, antiangiogenic, anti-inflammatory and antioxidant activities of Scyphocephalium ochocoa Warb. (Myristicaceae), medicinal plant from Gabon
Rick-Leonid Ngoua-Meye-Misso,Jean De La Croix Ndong,Cédric Sima-Obiang,Joseph Privat Ondo,Guy Roger Ndong-Atome,Felix Ovono Abessolo,Louis-Clément Obame-Engonga +6 more
TL;DR: In this paper, the authors carried out a phytochemical screening to determine the phenolic compounds content, to investigate the antiangiogenic, anti-inflammatory and antioxidant activities of water, water-ethanol and ethanol extracts of S. ochocoa.
Assessment of the Tumor Redox Status in Head and Neck Cancer by 62Cu-ATSM PET.
Tetsuya Tsujikawa,Satoko Asahi,Myungmi Oh,Yoshitaka Sato,Norihiko Narita,Akira Makino,Tetsuya Mori,Yasushi Kiyono,Tatsuro Tsuchida,Hirohiko Kimura,Shigeharu Fujieda,Hidehiko Okazawa +11 more
TL;DR: Tumor redox parameters measured by 62Cu-ATSM PET may be determinants of HNC patient outcomes and help define optimal patient-specific treatments and predict disease progression and cancer death.
References
Multidrug resistance in cancer: role of ATP–dependent transporters
TL;DR: The ability to predict and circumvent drug resistance is likely to improve chemotherapy, and it has become apparent that resistance exists against every effective drug, even the authors' newest agents.
Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation
Panu Jaakkola,David R. Mole,Ya-Min Tian,Michael I. Wilson,Janine Gielbert,Simon J. Gaskell,Alex von Kriegsheim,Holger F. Hebestreit,Mridul Mukherji,Christopher J. Schofield,Patrick H. Maxwell,Christopher W. Pugh,Peter J. Ratcliffe +12 more
TL;DR: It is shown that the interaction between human pVHL and a specific domain of the HIF-1α subunit is regulated through hydroxylation of a proline residue by an enzyme the authors have termed Hif-α prolyl-hydroxylase (HIF-PH).
5.6K
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Patrick H. Maxwell,Michael S. Wiesener,Gin-Wen Chang,Steven C. Clifford,Emma C. Vaux,Matthew Edward Cockman,Charles C. Wykoff,Christopher W. Pugh,Eamonn R. Maher,Peter J. Ratcliffe,Peter J. Ratcliffe +10 more
TL;DR: It is indicated that the interaction between HIF-1 and pVHL is iron dependent, and that it is necessary for the oxygen-dependent degradation of HIF α-subunits, which may underlie the angiogenic phenotype of VHL-associated tumours.
5.2K
An nrf2/small maf heterodimer mediates the induction of phase ii detoxifying enzyme genes through antioxidant response elements
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TL;DR: It is demonstrated that Nrf2 is essential for the transcriptional induction of phase II enzymes and the presence of a coordinate transcriptional regulatory mechanism for phase II enzyme genes and the nrf2-deficient mice may prove to be a very useful model for the in vivo analysis of chemical carcinogenesis and resistance to anti-cancer drugs.
3.9K
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Ken Itoh,Nobunao Wakabayashi,Yasutake Katoh,Tetsuro Ishii,Kazuhiko Igarashi,James Douglas Engel,James Douglas Engel,Masayuki Yamamoto +7 more
TL;DR: It is postulate that Keap1 and Nrf2 constitute a crucial cellular sensor for oxidative stress, and together mediate a key step in the signaling pathway that leads to transcriptional activation by this novel NRF2 nuclear shuttling mechanism.