Michael M. Gottesman
National Institutes of Health
505 Papers
11.5K Citations
Michael M. Gottesman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: P-glycoprotein & Cell culture. The author has an hindex of 115, co-authored 494 publications. Previous affiliations of Michael M. Gottesman include Heidelberg University & Laboratory of Molecular Biology.
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Papers
Multidrug resistance in cancer: role of ATP–dependent transporters
TL;DR: The ability to predict and circumvent drug resistance is likely to improve chemotherapy, and it has become apparent that resistance exists against every effective drug, even the authors' newest agents.
Mechanisms of cancer drug resistance
TL;DR: The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anti-cancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance as mentioned in this paper.
2.7K
Biochemical, cellular, and pharmacological aspects of the multidrug transporter
Suresh V. Ambudkar,Saibal Dey,Christine A. Hrycyna,Murali Ramachandra,Ira Pastan,Michael M. Gottesman +5 more
TL;DR: This review summarizes current research on the structure-function analysis of P-glycoprotein, its mechanism of action, and facts and speculations about its normal physiological role.
2K
Expression of a multidrug-resistance gene in human tumors and tissues
TL;DR: The results suggest that measurement of mdr1 RNA may prove to be a valuable tool in the design of chemotherapy protocols and controlled clinical studies will be required.
1.6K