Bridges between microtubules.
TL;DR: Evidence is presented that nonperiodic bridges exist between certain tubules and that these structures are attached to periodic binding sites on the microtubule wall, but that not all the binding sites are filled.
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Abstract: Bridges between microtubules have been studied with the electron microscope in the axostyle of Saccinobaculus and in various tubule systems of chicken testis, including the helix of tubules surrounding the elongating spermatid nucleus and the flagellum of the sperm tail. In addition to the previously described periodic bridges, evidence is presented that nonperiodic bridges exist between certain tubules. An analysis of axial spacing between adjacent nonperiodic bridges suggests that these structures are attached to periodic binding sites on the microtubule wall, but that not all the binding sites are filled. The bridges appear nonperiodic as a result of random occupancy of some fraction of the periodic sites. The distribution of these binding sites is related to the substructure of the microtubule wall as seen with negative staining and optical diffraction.
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Citations
Association of high-molecular-weight proteins with microtubules and their role in microtubule assembly in vitro
Douglas B. Murphy,Gary G. Borisy +1 more
TL;DR: It is demonstrated that the HMW associates with microtubules as a structural component projecting from the surface of the microtubule wall by facilitating the formation of ring structures which are apparently intermediates in polymerization.
550
The periodic association of MAP2 with brain microtubules in vitro.
TL;DR: A heat-stable fraction highly enriched for one of the MAPs, MAP2, devoid of MAP1, has been purified from calf neurotubules, lowering the critical concentration for tubulin assembly to 0.05 mg/ml and demonstrating a striking axial periodicity.
Information processing in microtubules.
Stuart R. Hameroff,R.C. Watt +1 more
TL;DR: Biological information functions could be explained by comparing microtubule structure and activities to Boolean switching matrices, parallel computers, and such technologies as transistor circuits, magnetic bubble memory, charge transfer devices, surface acoustic wave resonators, and/or holography.
231
Microtubule-associated proteins (MAPs) and the organization of actin filaments in vitro.
TL;DR: It is demonstrated that MAPs can bind to actin filaments and can induce the reversible formation of actin filament bundles in vitro, and that MAP-2 was the principal protein necessary for the formation of bundles.
171
Human chromosomes and centrioles as nucleating sites for the in vitro assembly of microtubules from bovine brain tubulin.
M McGill,B R Brinkley +1 more
TL;DR: It is indicated that HeLa chromosomes and centrioles can serve as nucleating sites for the assembly of microtubules from brain tubulin and should prove useful for experimental studies of spindle microtubule formation and chromosome movement in mammalian cells.
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