Zhao-Shan Liu

TL;DR: The study reveals that acetylation contributes to cGAS activity regulation and provides a potential therapy for treating DNA-mediated autoimmune diseases.

TL;DR: It is reported that GTPase-activating protein SH3 domain–binding protein 1 (G3BP1) is critical for DNA sensing and efficient activation of cGAS, a key sensor responsible for cytosolic DNA detection and EGCG-mediated inhibition of G3 BP1 provides a potential treatment forcGAS-related autoimmune diseases.

TL;DR: It is shown that NF-κB activating protein (NKAP) is critical for chromosome alignment through anchoring CENP-E to kinetochores and its dysregulation might contribute to tumorigenesis by causing chromosomal instability.

TL;DR: In this article, GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) was found to be critical for both intracellular DNA-and RNA-induced immune responses.