Xiaoli Xu
Shanghai Jiao Tong University
11 Papers
6 Citations
Xiaoli Xu is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Downregulation and upregulation & Breast cancer. The author has an hindex of 4, co-authored 7 publications.
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Papers
USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis.
Aihui Ma,Ming Tang,Li Zhang,Boshi Wang,Zhaojuan Yang,Yun Liu,Guiqin Xu,Lin Wu,Tiantian Jing,Xiaoli Xu,Shengli Yang,Yongzhong Liu +11 more
TL;DR: It is demonstrated that hyperactivation of the deubiquitinase USP1 contributes to breast cancer metastasis, and pharmacological intervention ofUSP1 function by pimozide or ML323 significantly represses breast Cancer metastasis in mice, suggesting a rationale for using USP 1 inhibitors for treatment of patients with breast cancer.
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Deubiquitination of the repressor E2F6 by USP22 facilitates AKT activation and tumor growth in hepatocellular carcinoma
Tiantian Jing,Boshi Wang,Zhaojuan Yang,Yun Liu,Guiqin Xu,Xiaoli Xu,Kun Jiao,Zehong Chen,Lvzhu Xiang,Li Zhang,Yongzhong Liu +10 more
TL;DR: In this article, the deubiquitinase USP22 interacts with and stabilizes E2F6, resulting in the transcriptional repression of DUSP1.
16
Correction to: USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis
Aihui Ma,Ming Tang,Li Zhang,Boshi Wang,Zhaojuan Yang,Yun Liu,Guiqin Xu,Lin Wu,Tiantian Jing,Xiaoli Xu,Shengli Yang,Yongzhong Liu +11 more
TL;DR: Following the publication of this article, the authors noted an error in Fig. 6b, where the upper part of the panel was inadvertently inverted.
POH1 facilitates pancreatic carcinogenesis through MYC-driven acinar-to-ductal metaplasia and is a potential therapeutic target.
Tiantian Jing,Xiaoli Xu,Chengsi Wu,Dian-Fang Wei,Lili Yuan,Yiwen Huang,Yizhen Liu,Boshi Wang +7 more
TL;DR: It is suggested that pancreatic-specific deletion of Poh1 alleles attenuates ADM and impairs pancreatic carcinogenesis, improving murine survival and highlighting POH1 as a promising therapeutic target for PDAC treatment.
2
HERVH-derived eRNA activates a super-enhancer–driven ALDH1A3/SAT1 axis to promote ferroptosis escape and pancreatic cancer development
Lili Yuan,Jiahui Yu,Xiaoli Xu,Yiwen Huang,Dian-Fang Wei,Zhenbo Hou,Huizhen Nie,Tiantian Jing,Yizhen Liu,Boshi Wang +9 more
TL;DR: HERVH-derived eRNAs activate a super-enhancer-driven ALDH1A3/SAT1 axis, promoting ferroptosis escape and pancreatic cancer development by inhibiting lipid peroxidation and ferroptosis, and highlighting the KLF5/HERVH/ALDH1A3 pathway as a potential therapeutic target.