Aihui Ma
Shanghai Jiao Tong University
19 Papers
9 Citations
Aihui Ma is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Downregulation and upregulation & FOXP3. The author has an hindex of 10, co-authored 17 publications.
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Papers
POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation
Boshi Wang,Aihui Ma,Li Zhang,Weilin Jin,Yu Qian,Guiqin Xu,Bijun Qiu,Zhaojuan Yang,Yun Liu,Qiang Xia,Yongzhong Liu +10 more
TL;DR: It is demonstrated that the deubiquitylase POH1 stabilizes E2F1 protein through binding to and deubanquitylating E1F1, which may contribute to the development of liver cancer.
Transcription factor KLF9 suppresses the growth of hepatocellular carcinoma cells in vivo and positively regulates p53 expression.
TL;DR: E ectopic expression of KLF9 was sufficient to delay the onset of tumors and to promote regression of the established tumors in vivo, suggesting that KLF 9 plays a critical role in HCC development and that pharmacological or genetic activation of KLf9 may have potential in the treatment of HCC.
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USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis.
Aihui Ma,Ming Tang,Li Zhang,Boshi Wang,Zhaojuan Yang,Yun Liu,Guiqin Xu,Lin Wu,Tiantian Jing,Xiaoli Xu,Shengli Yang,Yongzhong Liu +11 more
TL;DR: It is demonstrated that hyperactivation of the deubiquitinase USP1 contributes to breast cancer metastasis, and pharmacological intervention ofUSP1 function by pimozide or ML323 significantly represses breast Cancer metastasis in mice, suggesting a rationale for using USP 1 inhibitors for treatment of patients with breast cancer.
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Transient mTOR inhibition facilitates continuous growth of liver tumors by modulating the maintenance of CD133+ cell populations
TL;DR: In H-Ras-transformed mouse liver tumor cells, it is found that pharmacological inhibition of mTOR with rapamycin greatly increased not only the CD133+ populations both in vitro and in vivo but also the expression of stem cell-like genes.
Myeloid TGF-β signaling contributes to colitis-associated tumorigenesis in mice
Jingyi Li,Yun Liu,Boshi Wang,Yingqian Xu,Aihui Ma,Feng Zhang,Chao Ge,Zhaojuan Yang,Jinjun Li,Yongzhong Liu +9 more
TL;DR: It is demonstrated that transforming growth factor-β (TGF-β) signaling in colonic myeloid cells is significantly involved in the development of CAC and modulates intestinal inflammation and significantly promotes tumorigenesis in theDevelopment of colitis-associated colon cancer.
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