Wesley Won
Genentech
8 Papers
101 Citations
Wesley Won is an academic researcher from Genentech. The author has contributed to research in topics: Apolipoprotein B & Cholesterol. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Wesley Won include Albert Einstein College of Medicine & Medical University of South Carolina.
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Papers
Growth hormone secretagogues stimulate the hypothalamic-pituitary-adrenal axis and are diabetogenic in the zucker diabetic fatty rat
Ross G. Clark,G. B. Thomas,Deborah L. Mortensen,Wesley Won,Y. H. Ma,E.E. Tomlinson,Keith M. Fairhall,I. C. A. F. Robinson +7 more
TL;DR: Both G7039 and hGH treatment stimulated growth in ZDF rats, but greatly worsened diabetes, unless IGF-1 was coadministered, and the magnitude of these adverse effects in the ZDF animals suggest that chronic administration of GHRP analogs with cortisol-releasing activity to obese or diabetes-prone individuals warrants careful evaluation.
Lipoprotein subclass profiles of hyperlipidemic diabetic mice measured by nuclear magnetic resonance spectroscopy.
Samar M. Hammad,Lyn Powell-Braxton,James D Otvos,Leslie Eldridge,Wesley Won,Timothy J. Lyons +5 more
TL;DR: NMR analysis reveals lipoprotein subclass distributions and the effects of genetic modification and diabetes in mice, but lack of particles the size of human small LDL and small HDL may limit the relevance of the present animal model to human disease.
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Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarction
Minoru Hongo,Eric M. Sentianin,Nobuaki Tanaka,Lan Mao,M. Dan McKirnan,Ross G. Clark,Wesley Won,Kenneth R. Chien,John Ross +8 more
TL;DR: Short-term GH given in sequence after chronic AT1 blockade had favorable actions on the failing heart and peripheral circulation by increasing LV wall thickness with partial reversal of unfavorable remodeling, lowering of vascular resistance, improvement of LV contractility, and enhanced LV systolic function and cardiac index relatively late after experimental MI.
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Nephropathy in a hypercholesterolemic mouse model with streptozotocin-induced diabetes.
Samar M. Hammad,Debra J. Hazen-Martin,Mimi Sohn,Leslie Eldridge,Lyn Powell-Braxton,Wesley Won,Timothy J. Lyons +6 more
TL;DR: In this animal model, preexisting hypercholesterolemia did not exacerbate either glomerular lesions of diabetes (collagen accumulation, basement membrane thickening) or albuminuria, but appeared to mitigate these effects.
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Subject Index Vol. 26, 2003
Bolesław Rutkowski,Tomas Lenz,Thomas Haak,Joanna Malek,Hermann Josef Gröne,Helmut Geiger,Jan Gossmann,C. Birk,K.-P. Richter,Dan Yang Huang,C. Piesch,Gerd Luippold,Volker Vallon,Marcus Baumann,Wolfgang Niebel,Andreas Kribben,Thomas Philipp,Uwe Heemann,Leszek Tylicki,Walter H. Hörl,Ho Jae Han,Ji Yeong Park,Yun Jung Lee,Soo Hyun Park,Tobias Saam,Heimo Ehmke,Christian S. Haas,Eberhard Ritz,Kerstin Amann,Y. Luther,Christos Bantis,Katrin Ivens,K. Fehsel,V. Kolb-Bachhofen,Peter Heering,Samar M. Hammad,Debra J. Hazen-Martin,Mimi Sohn,Leslie Eldridge,Lyn Powell-Braxton,Wesley Won,Timothy J. Lyons,Pavlína Zemanová,Karel Opatrný,Sylvie Opatrná,Ladislav Vít,Frantisek Sefrna,Jaroslav Racek +47 more