Veronica Estrella
University of South Florida
26 Papers
67 Citations
Veronica Estrella is an academic researcher from University of South Florida. The author has contributed to research in topics: Medicine & Acidosis. The author has an hindex of 14, co-authored 24 publications. Previous affiliations of Veronica Estrella include University of Miami & Moffitt Cancer Center.
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Papers
Acidity generated by the tumor microenvironment drives local invasion
Veronica Estrella,Tingan Chen,Mark C. Lloyd,Jonathan W. Wojtkowiak,Heather H. Cornnell,Arig Ibrahim-Hashim,Kate M. Bailey,Yoganand Balagurunathan,Jennifer M. Rothberg,Bonnie F. Sloane,Joseph O. Johnson,Robert A. Gatenby,Robert J. Gillies +12 more
TL;DR: Oral administration of sodium bicarbonate was sufficient to increase peritumoral pH and inhibit tumor growth and local invasion in a preclinical model, supporting the acid-mediated invasion hypothesis.
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A physical sciences network characterization of non-tumorigenic and metastatic cells
David B. Agus,Jenolyn F. Alexander,Wadih Arap,Shashaanka Ashili,Joseph E. Aslan,Robert H. Austin,Vadim Backman,Kelly Bethel,Richard Bonneau,Wei Chiang Chen,Chira Chen-Tanyolac,Nathan C. Choi,Steven A. Curley,Matthew R. Dallas,Dhwanil Damania,Paul Davies,Paolo Decuzzi,Laura E. Dickinson,Luis Estévez-Salmerón,Veronica Estrella,Mauro Ferrari,Claudia Fischbach,Jasmine Foo,Stephanie I. Fraley,Christian Frantz,Alexander Fuhrmann,Philippe Gascard,Robert A. Gatenby,Yue Geng,Sharon Gerecht,Robert J. Gillies,Biana Godin,William M. Grady,William M. Grady,Alex Greenfield,Courtney Hemphill,Barbara L. Hempstead,Abigail Hielscher,W. Daniel Hillis,Eric C. Holland,Arig Ibrahim-Hashim,Tyler Jacks,Roger H. Johnson,Ahyoung Joo,Jonathan E. Katz,Laimonas Kelbauskas,Carl Kesselman,Michael R. King,Konstantinos Konstantopoulos,Casey M. Kraning-Rush,Peter Kuhn,Kevin S. Kung,Brian J. Kwee,Johnathon N. Lakins,Guillaume Lambert,David Liao,Jonathan D. Licht,Jan Liphardt,Jan Liphardt,Liyu Liu,Mark C. Lloyd,Anna Lyubimova,Parag Mallick,Parag Mallick,John F. Marko,Owen J. T. McCarty,Deirdre R. Meldrum,Franziska Michor,Shannon M. Mumenthaler,Vivek Nandakumar,Thomas V. O'Halloran,Steve Oh,Renata Pasqualini,Matthew J. Paszek,Kevin G. Philips,Christopher S. Poultney,Kuldeepsinh Rana,Cynthia A. Reinhart-King,Robert Ros,Gregg L. Semenza,Patti Senechal,Michael L. Shuler,Srimeenakshi Srinivasan,Jack R. Staunton,Yolanda Stypula,Hariharan Subramanian,Thea D. Tlsty,Garth W. Tormoen,Yiider Tseng,Yiider Tseng,Alexander van Oudenaarden,Scott S. Verbridge,Scott S. Verbridge,Jenny C. Wan,Valerie M. Weaver,Jonathan Widom,Christine Will,Denis Wirtz,Jonathan W. Wojtkowiak,Pei Hsun Wu +99 more
TL;DR: Comparisons of the non-tumorigenic MCF-10A and metastatic MDA-MB-231 breast epithelial cell lines, commonly used as models of cancer metastasis, reveal dramatic differences in their mechanics, migration, adhesion, oxygen response, and proteomic profiles.
Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane.
Mehdi Damaghi,Narges K. Tafreshi,Mark C. Lloyd,Robert Sprung,Veronica Estrella,Jonathan W. Wojtkowiak,David L. Morse,John M. Koomen,Marilyn M. Bui,Robert A. Gatenby,Robert J. Gillies +10 more
TL;DR: It is shown that the depletion of LAMP2 is sufficient to increase acidosis-mediated toxicity and a potential adaptive mechanism, wherein cells chronically exposed to an acidic environment translocate lysosomal proteins to their surface, thus protecting the plasmalemma from acid-induced hydrolysis is suggested.
Acidosis and cancer: from mechanism to neutralization
TL;DR: This review will revisit the causes and consequences of acidosis by summarizing strategies used by cancer cells to adapt to acidosis, and how neutralization of acidity can be used to inhibit carcinogenesis and metastasis and improve anti-cancer immunotherapy.
T-cells produce acidic niches in lymph nodes to suppress their own effector functions
Hao Wu,Veronica Estrella,Matthew Beatty,Dominique Abrahams,Asmaa El-Kenawi,Shonagh Russell,Arig Ibrahim-Hashim,Dario Livio Longo,Yana K. Reshetnyak,Anna Moshnikova,Oleg A. Andreev,Kimberly Luddy,Mehdi Damaghi,Krithika Kodumudi,Smitha Pillai,Pedro M. Enriquez-Navas,Shari Pilon-Thomas,Pawel Swietach,Robert J. Gillies +18 more
TL;DR: The authors show that the acidic extracellular pH in lymph node paracortical zones limits cytokine production by effector T-cells, but does not alter their activation by antigen-presenting cells.