Tun Nyunt
University of California, Davis
5 Papers
33 Citations
Tun Nyunt is an academic researcher from University of California, Davis. The author has contributed to research in topics: Oxidative stress & Activating transcription factor. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Tun Nyunt include Yale University.
Chat about Author
Papers
Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations.
Victoria C. Cogger,Gregory P. McNerney,Tun Nyunt,Laurie D. DeLeve,Peter McCourt,Bård Smedsrød,David G. Le Couteur,Thomas R Huser +7 more
TL;DR: Three-dimensional structured illumination microscopy has enabled the unlimited power of fluorescent immunostaining and co-localization to reveal new structural and functional information about fenestrations and sieve plates.
94
Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways
Hnin Hnin Aung,Robin Altman,Tun Nyunt,Jeffrey Kim,Saivageethi Nuthikattu,Madhu S. Budamagunta,John C. Voss,Dennis W Wilson,John C. Rutledge,Amparo C Villablanca +9 more
TL;DR: The hypothesis that TGRL lipolysis products cause lipotoxic injury to brain microvascular endothelium by generating increased mitochondrial superoxide radical generation, upregulation of activating transcription factor 3 (ATF3)-dependent inflammatory pathways, and activation of cellular oxidative stress and apoptotic pathways is investigated.
41
Mitochondrial oxidative stress-induced transcript variants of ATF3 mediate lipotoxic brain microvascular injury.
Tun Nyunt,Monica Britton,Kwanjeera Wanichthanarak,Madhu S. Budamagunta,John C. Voss,Dennis W Wilson,John C. Rutledge,Hnin Hnin Aung +7 more
TL;DR: The data indicates that ATF3-T4 predominantly regulates the TL-induced brain microvascular inflammation and TNF signaling and CPT1A1 siRNA knockdown suppresses oxidative stress and prevents mitochondrial dysfunction and vascular inflammation in TL treated HBMECs.
36
Dynamics of neutrophil membrane compliance and microstructure probed with a micropipet-based piconewton force transducer.
Scott I. Simon,Tun Nyunt,Kathryn Florine-Casteel,Ken Ritchie,H.P. Ting-Beall,Evan Evans,David Needham +6 more
TL;DR: The utility of the biointerface probe for measuring local surface compliance and microstructure of living cells is demonstrated, and three distinct material responses are revealed.
20
TGRL Lipolysis Products Induce Stress Protein ATF3 via the TGF-β Receptor Pathway in Human Aortic Endothelial Cells
Larissa Eiselein,Tun Nyunt,Michael W. Lamé,Kit Fai Ng,Dennis W Wilson,John C. Rutledge,Hnin Hnin Aung +6 more
TL;DR: It is demonstrated that triglyceride-rich lipoproteins (TGRL) lipolysis products activate MAP kinase stress associated JNK/c-Jun pathways resulting in up-regulation of ATF3, pro-inflammatory genes and induction of apoptosis in human aortic endothelial cells.