David Needham
Duke University
197 Papers
2.4K Citations
David Needham is an academic researcher from Duke University. The author has contributed to research in topics: Bilayer & Liposome. The author has an hindex of 62, co-authored 186 publications. Previous affiliations of David Needham include University of California, Irvine & University of Nottingham.
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Papers
Effect of Chain Length and Unsaturation on Elasticity of Lipid Bilayers
TL;DR: To test this hypothesis, peak-to-peak headgroup thicknesses h(pp) of bilayers were obtained from x-ray diffraction of multibilayer arrays at controlled relative humidities and showed that poly-cis unsaturated chain bilayers are thinner and more flexible than saturated/monounsaturated chain Bilayers.
1.9K
Elastic deformation and failure of lipid bilayer membranes containing cholesterol.
David Needham,R. S. Nunn +1 more
TL;DR: The results indicated that the presence of cholesterol is the single most influential factor in increasing bilayer cohesion, but only for lipids where both chains are saturated, or mono- or diunsaturated, and multiple unsaturation in both lipid chains inhibits the condensing effect of cholesterol in bilayers.
896
•Journal Article
A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model.
TL;DR: A new lipid formulation containing doxorubicin that has been optimized for both mild hyperthermic temperatures and rapid release times is described, found to be significantly more effective than free drug or current liposome formulations at reducing tumor growth in a human squamous cell carcinoma xenograft line.
805
•Journal Article
Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release.
Garheng Kong,Gopal Anyarambhatla,William P. Petros,R. D. Braun,Colvin Om,David Needham,Mark W. Dewhirst +6 more
TL;DR: With HT, the DOX concentrations and fluorescence were tightly correlated with tumor growth delay, indicating that adequate (increased) drug delivery can be predictive of therapeutic effect and demonstrates the importance of rapid drug release from the drug carriers at the tumor site.
541
Water permeability and mechanical strength of polyunsaturated lipid bilayers.
TL;DR: The correlation between the prominent changes in lysis tension and water permeability indicate that major changes occur in chain packing and cohesive interactions when two or more cis-double bonds alternate with saturated bonds along a chain.
508