Tara M. Randis
New York University
51 Papers
195 Citations
Tara M. Randis is an academic researcher from New York University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 20, co-authored 40 publications. Previous affiliations of Tara M. Randis include Columbia University.
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Papers
Role of Pore-Forming Toxins in Bacterial Infectious Diseases
TL;DR: Common functions of PFTs include disruption of epithelial barrier function and evasion of host immune responses, which contribute to bacterial growth and spreading, make this group of toxins an attractive target for the development of new virulence-targeted therapies that may have broad activity against human pathogens.
389
Inerolysin, a Cholesterol-Dependent Cytolysin Produced by Lactobacillus iners
Ryan Rampersaud,Paul J. Planet,Tara M. Randis,Ritwij Kulkarni,Jorge L. Aguilar,Robert I. Lehrer,Adam J. Ratner +6 more
TL;DR: The identification and molecular characterization of a protein toxin produced by L. iners, inerolysin (INY), is presented, a pore-forming toxin that is activated by reducing agents and inhibited by excess cholesterol and represents a new target for studies directed at understanding the role of L.Iners in states of health and disease at the vaginal mucosal surface.
135
Pregnancy-specific association of vitamin D deficiency and bacterial vaginosis
TL;DR: VDD was a modifiable risk factor for BV among pregnant women; evaluation of vitamin D supplementation for prevention or adjunct therapy of BV in pregnancy is warranted.
131
Group B Streptococcus and the Vaginal Microbiota
Geoffrey H. Rosen,Tara M. Randis,Purnahamsi Desai,Katherine J. Sapra,Bing Ma,Pawel Gajer,Michael S. Humphrys,Jacques Ravel,Shari E. Gelber,Adam J. Ratner,Adam J. Ratner +10 more
TL;DR: Vaginal microbiota CST and α-diversity are not related to GBS status, but specific microbial taxa are associated with colonization of this important human pathogen, highlighting a potential role for the microbiota in promotion or inhibition of GBS colonization.
The essential genome of Streptococcus agalactiae.
Thomas A. Hooven,Andrew J. Catomeris,Leor H. Akabas,Tara M. Randis,Duncan J. Maskell,Sarah Peters,Sandra Ott,Ivette Santana-Cruz,Luke J. Tallon,Hervé Tettelin,Adam J. Ratner +10 more
TL;DR: The baseline fitness assignments will be a valuable tool for GBS researchers and the Tn-seq system has the potential to reveal key pathogenesis gene networks and potential therapeutic/preventative targets.