Tae-Wook Chun
National Institutes of Health
114 Papers
614 Citations
Tae-Wook Chun is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Viremia. The author has an hindex of 51, co-authored 96 publications.
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Papers
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
Tae-Wook Chun,Lieven Stuyver,Stephanie B. Mizell,Linda A. Ehler,Jo Ann M. Mican,Michael Baseler,Alun L. Lloyd,Martin A. Nowak,Anthony S. Fauci +8 more
TL;DR: Highly purified CD4+ T cells from patients receiving HAART with an average treatment time of 10 months and with undetectable plasma viremia carried integrated proviral DNA and were capable of producing infectious virus upon cellular activation in vitro, suggesting persistent active virus replication in vivo.
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Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
Susan Moir,Jason Ho,Angela Malaspina,Wei-wei Wang,Angela C. DiPoto,Marie A. O'Shea,Gregg Roby,Shyam Kottilil,James Arthos,Michael A. Proschan,Tae-Wook Chun,Anthony S. Fauci +11 more
TL;DR: HIV-associated premature exhaustion of B cells may contribute to poor antibody responses against HIV in infected individuals, and strikingly, HIV- specific responses were enriched in these exhausted tissuelike memory B cells, whereas total immunoglobulin and influenza-specific responses were enrichment in classical memory B Cells.
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
R. Brad Jones,Lishomwa C. Ndhlovu,Jason D. Barbour,Prameet M. Sheth,Aashish R. Jha,Brian Long,Jessica Wong,Malathy Satkunarajah,Marc Schweneker,Joan M. Chapman,Gabor Gyenes,Bahareh Vali,Martin D. Hyrcza,Feng Yun Yue,Colin Kovacs,Aref Sassi,Mona R. Loutfy,Roberta Halpenny,Desmond Persad,Gerald Spotts,Frederick Hecht,Tae-Wook Chun,Joseph M. McCune,Rupert Kaul,James M. Rini,Douglas F. Nixon,Mario A. Ostrowski +26 more
TL;DR: Blocking the Tim-3 signaling pathway restored proliferation and enhanced cytokine production in HIV-1–specific T cells and represents a novel target for the therapeutic reversal of HIV–1–associated T cell dysfunction.
Pathogenic Mechanisms of HIV Disease
TL;DR: Not only has the introduction of effective antiretroviral therapy greatly diminished the morbidity and mortality associated with HIV disease progression, it has also provided new avenues of research toward delineating the mechanisms of HIV-induced pathogenesis.
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Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption
Katharine J. Bar,Michael C. Sneller,Linda Harrison,J. Shawn Justement,Edgar T. Overton,Mary E. Petrone,D. Brenda Salantes,Catherine Seamon,Benjamin Scheinfeld,Richard Kwan,Gerald H. Learn,Michael A. Proschan,Edward F. Kreider,Jana Blazkova,Mark Bardsley,Eric W. Refsland,Michael Messer,Katherine E Clarridge,Nancy B Tustin,Patrick J Madden,KaSaundra Oden,Sijy O'Dell,Bernadette Jarocki,Andrea Shiakolas,Randall Tressler,Nicole A. Doria-Rose,Robert T. Bailer,Julie E. Ledgerwood,Edmund V. Capparelli,Rebecca M. Lynch,Barney S. Graham,Susan Moir,Richard A. Koup,John R. Mascola,James A. Hoxie,Anthony S. Fauci,Pablo Tebas,Tae-Wook Chun +37 more
TL;DR: Analyses of virus populations before ART as well as before and after ART interruption showed that VRC01 exerted pressure on rebounding virus, resulting in restriction of recrudescent viruses and selection for preexisting and emerging antibody neutralization-resistant virus.
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