Bahareh Vali
University of Toronto
7 Papers
34 Citations
Bahareh Vali is an academic researcher from University of Toronto. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 6, co-authored 7 publications.
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Papers
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
R. Brad Jones,Lishomwa C. Ndhlovu,Jason D. Barbour,Prameet M. Sheth,Aashish R. Jha,Brian Long,Jessica Wong,Malathy Satkunarajah,Marc Schweneker,Joan M. Chapman,Gabor Gyenes,Bahareh Vali,Martin D. Hyrcza,Feng Yun Yue,Colin Kovacs,Aref Sassi,Mona R. Loutfy,Roberta Halpenny,Desmond Persad,Gerald Spotts,Frederick Hecht,Tae-Wook Chun,Joseph M. McCune,Rupert Kaul,James M. Rini,Douglas F. Nixon,Mario A. Ostrowski +26 more
TL;DR: Blocking the Tim-3 signaling pathway restored proliferation and enhanced cytokine production in HIV-1–specific T cells and represents a novel target for the therapeutic reversal of HIV–1–associated T cell dysfunction.
Epigallocatechin-3-gallate increases the formation of mineralized bone nodules by human osteoblast-like cells.
TL;DR: The present study demonstrates the effects of EGCG on the formation of mineralized bone nodules by SaOS-2 human osteoblast (HOB)-like cells and suggests that E GCG may have beneficial effects on bone health.
HCV‐specific T cells in HCV/HIV co‐infection show elevated frequencies of dual Tim‐3/PD‐1 expression that correlate with liver disease progression
Bahareh Vali,R. Brad Jones,Ali Sakhdari,Prameet M. Sheth,Kiera L. Clayton,Feng-Yun Yue,Gabor Gyenes,David Wong,Marina B. Klein,Sahar Saeed,Erika Benko,Colin Kovacs,Rupert Kaul,Rupert Kaul,Mario A. Ostrowski,Mario A. Ostrowski +15 more
TL;DR: It is demonstrated that co‐expression of Tim‐3 and PD‐1 may play a significant role in HCV‐specific T‐cell dysfunction, especially in the setting of HIV co‐infection.
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Tim-3 Negatively Regulates Cytotoxicity in Exhausted CD8+ T Cells in HIV Infection
Ali Sakhdari,Shariq Mujib,Bahareh Vali,Feng Yun Yue,Sonya A. MacParland,Kiera L. Clayton,Richard Bradley Jones,J Liu,Erika Yue Lee,Erika Benko,Colin Kovacs,Jennifer L. Gommerman,Rupert Kaul,Mario A. Ostrowski +13 more
TL;DR: The Tim-3 receptor, in addition to acting as a terminator for cytokine producing and proliferative functions of CTLs, can also down-regulate the CD8+ T cell cytotoxic function through inhibition of degranulation and perforin and granzyme secretion.
HIV-specific T-cells accumulate in the liver in HCV/HIV co-infection.
Bahareh Vali,Feng Yun Yue,R. Brad Jones,Prameet M. Sheth,Rupert Kaul,Michael R. Betts,David Wong,Colin Kovacs,Mona Loutfy,Andrew Common,Roberta Halpenny,Mario A. Ostrowski,Mario A. Ostrowski +12 more
TL;DR: The accumulation of functional HIV-specific T-cells in the liver during HCV/HIV co-infection may represent a bystander role for HIV in inducing faster progression of liver disease.