Philip D. Gregory
Sangamo BioSciences
178 Papers
2.4K Citations
Philip D. Gregory is an academic researcher from Sangamo BioSciences. The author has contributed to research in topics: Zinc finger nuclease & Zinc finger. The author has an hindex of 76, co-authored 188 publications. Previous affiliations of Philip D. Gregory include Vita-Salute San Raffaele University & University of Texas at Austin.
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Papers
A TALE nuclease architecture for efficient genome editing
Jeffrey C. Miller,Siyuan Tan,Guijuan Qiao,Kyle A. Barlow,Jianbin Wang,Danny F Xia,Xiangdong Meng,David Paschon,Elo Leung,Sarah J. Hinkley,Gladys P Dulay,Kevin Hua,Irina Ankoudinova,Gregory J. Cost,Fyodor D. Urnov,H. Steve Zhang,Michael C. Holmes,Lei Zhang,Philip D. Gregory,Edward J. Rebar +19 more
TL;DR: This study identifies TALE truncation variants that efficiently cleave DNA when linked to the catalytic domain of FokI and uses them to generate discrete edits or small deletions within endogenous human NTF3 and CCR5 genes at efficiencies of up to 25%.
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Genome editing with engineered zinc finger nucleases
TL;DR: A broad range of outcomes has resulted from the application of the same core technology: targeted genome cleavage by engineered, sequence-specific zinc finger nucleases followed by gene modification during subsequent repair.
Highly efficient endogenous human gene correction using designed zinc-finger nucleases
Fyodor D. Urnov,Jeffrey C. Miller,Ya-Li Lee,Christian Beauséjour,Jeremy M. Rock,Sheldon Augustus,Andrew C. Jamieson,Matthew H. Porteus,Philip D. Gregory,Michael C. Holmes +9 more
TL;DR: It is shown that zinc-finger nucleases designed against an X-linked severe combined immune deficiency mutation in the IL2Rγ gene yielded more than 18% gene-modified human cells without selection, raising the possibility of strategies based on zinc- finger nucleases for the treatment of disease.
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.
Pablo Tebas,David Stein,Winson Tang,Ian Frank,Shelley Wang,Gary Lee,S. Kaye Spratt,Richard T. Surosky,Martin Giedlin,Geoff Nichol,Michael C. Holmes,Philip D. Gregory,Dale G. Ando,Michael Kalos,Ronald G. Collman,Gwendolyn Binder-Scholl,Gabriela Plesa,Wei-Ting Hwang,Bruce L. Levine,Carl H. June +19 more
TL;DR: CCR5-modified autologous CD4 T-cell infusions are safe within the limits of this study, and HIV RNA became undetectable in one of four patients who could be evaluated.
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Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
Aaron D Goldberg,Laura A. Banaszynski,Kyung-Min Noh,Peter W. Lewis,Simon J. Elsaesser,Sonja C. Stadler,Scott Dewell,Martin J. Law,Xingyi Guo,Xuan Li,Duancheng Wen,Duancheng Wen,Ariane Chapgier,Russell Dekelver,Jeffrey C. Miller,Ya Li Lee,Elizabeth A. Boydston,Michael C. Holmes,Philip D. Gregory,John M. Greally,Shahin Rafii,Shahin Rafii,Chingwen Yang,Peter J. Scambler,David Garrick,Richard J. Gibbons,Douglas R. Higgs,Ileana M. Cristea,Fyodor D. Urnov,Deyou Zheng,C. David Allis +30 more
TL;DR: It is demonstrated that multiple and distinct factors are responsible for H3.3 localization at specific genomic locations in mammalian cells.
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