Paul D. Doodes
Rush University Medical Center
10 Papers
330 Citations
Paul D. Doodes is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Arthritis & T cell. The author has an hindex of 7, co-authored 10 publications.
Chat about Author
Papers
IL-27 Induces a Th1 Immune Response and Susceptibility to Experimental Arthritis
TL;DR: The results indicate that IL-27 is critically involved in the induction of inflammation in PGIA, and functions by inducing the differentiation of IFN-γ-producing T cells in vivo that are essential for the development of arthritis.
169
Expression of CD80/86 on B Cells Is Essential for Autoreactive T Cell Activation and the Development of Arthritis
TL;DR: It is demonstrated that a CD80/86:CD28 costimulatory interaction between B cells and T cells is required for autoreactive T cell activation and the induction of arthritis but not for B cell autoantibody production.
132
Development of proteoglycan-induced arthritis is independent of IL-17.
Paul D. Doodes,Yanxia Cao,Keith M. Hamel,Yumei Wang,Balint Farkas,Yoichiro Iwakura,Alison Finnegan +6 more
TL;DR: Assessment of the progression of arthritis in IL-17-deficient (IL-17−/−) mice found the onset and severity of arthritis were equivalent in wild-type (WT), and the production of other proinflammatory mediators is sufficient to compensate for the loss of IL- 17 in PGIA.
Suppression of Proteoglycan-Induced Arthritis by Anti-CD20 B Cell Depletion Therapy Is Mediated by Reduction in Autoantibodies and CD4+ T Cell Reactivity
Keith M. Hamel,Paul D. Doodes,Yanxia Cao,Yumei Wang,Jeffrey Martinson,Robert Dunn,Marilyn R. Kehry,Balint Farkas,Alison Finnegan +8 more
TL;DR: Overall, B cell depletion during PGIA significantly reduced disease and inhibited both autoreactive B cell and T cell function.
92
IFN-γ Regulates the Requirement for IL-17 in Proteoglycan-Induced Arthritis
Paul D. Doodes,Yanxia Cao,Keith M. Hamel,Yumei Wang,Rachel Rodeghero,Katalin Mikecz,Tibor T. Glant,Yoichiro Iwakura,Alison Finnegan +8 more
TL;DR: It is demonstrated that both IFN-γ and IL-17 have the potential to induce PGIA, but it is the strength of the IFn-γ response that regulates the contribution of each of these Th effector cytokines to disease.
84