Robert Dunn

TL;DR: It is found that selective B cell depletion in apolipoprotein E-deficient mice using a well-characterized mAb to mouse CD20 reduced atherosclerosis development and progression without affecting the hyperlipidemia imposed by a high-fat diet.

TL;DR: Whereas successful B cell depletion is a promising therapy for lupus, at least some patients might be resistant to the therapy as a byproduct of the autoimmune condition itself, and this was true with multiple anti-CD20 Abs, including a new anti-mouse CD20 Ab, and in several different autoimmune-prone strains.

TL;DR: It is shown that Th1 cells mediate noncytolytic antiviral protection independent of direct lysis through local secretion of IFN-γ after herpes simplex virus (HSV) 2 infection.

TL;DR: Overall, B cell depletion during PGIA significantly reduced disease and inhibited both autoreactive B cell and T cell function.