Paolo Manunta
Vita-Salute San Raffaele University
224 Papers
1.7K Citations
Paolo Manunta is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Medicine & Essential hypertension. The author has an hindex of 50, co-authored 176 publications. Previous affiliations of Paolo Manunta include University of Maryland, Baltimore & University of Milan.
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Papers
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Elizabeth K. Speliotes,Elizabeth K. Speliotes,Cristen J. Willer,Sonja I. Berndt,Keri L. Monda,Gudmar Thorleifsson,Anne U. Jackson,Hana Lango Allen,Cecilia M. Lindgren,Jian'an Luan,Reedik Maegi,Joshua C. Randall,Sailaja Vedantam,Thomas W. Winkler,Lu Qi,Lu Qi,Tsegaselassie Workalemahu,Iris M. Heid,Valgerdur Steinthorsdottir,Heather M. Stringham,Michael N. Weedon,Eleanor Wheeler,Andrew R. Wood,Teresa Ferreira,Robert J. Weyant,Ayellet V. Segrè,Ayellet V. Segrè,Karol Estrada,Liming Liang,James Nemesh,James Nemesh,Ju-Hyun Park,Stefan Gustafsson,Tuomas O. Kilpelaenen,Jian Yang,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Tõnu Esko,Mary F. Feitosa,Zoltán Kutalik,Massimo Mangino,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,André Scherag,Albert V. Smith,Ryan P. Welch,Jing Hua Zhao,Katja K.H. Aben,Devin Absher,Najaf Amin,Anna L. Dixon,Eva Fisher,Nicole L. Glazer,Michael E. Goddard,Nancy L. Heard-Costa,Volker Hoesel,Jouke-Jan Hottenga,Åsa Johansson,Åsa Johansson,Toby Johnson,Shamika Ketkar,Claudia Lamina,Shengxu Li,Miriam F. Moffatt,Richard H. Myers,Narisu Narisu,John R. B. Perry,Marjolein Peters,Michael Preuss,Samuli Ripatti,Fernando Rivadeneira,Camilla H. Sandholt,Laura J. Scott,Nicholas J. Timpson,Jonathan Tyrer,Sophie van Wingerden,Richard M. Watanabe,Charles C. White,Fredrik Wiklund,Christina Barlassina,Daniel I. Chasman,Daniel I. Chasman,Mark E. Cooper,John-Olov Jansson,Robert Lawrence,Niina Pellikka,Inga Prokopenko,Jianxin Shi,Elisabeth Thiering,Helene Alavere,Maria Teresa Sciarrone Alibrandi,Peter Almgren,Alice M. Arnold,Thor Aspelund,Larry D. Atwood,Beverley Balkau,Anthony J. Balmforth,Amanda J. Bennett,Yoav Ben-Shlomo,Richard N. Bergman,Sven Bergmann,Heike Biebermann,Alexandra I. F. Blakemore,Tanja Boes,Lori L. Bonnycastle,Stefan R. Bornstein,Morris Brown,Thomas A. Buchanan,Fabio Busonero,Harry Campbell,Francesco P. Cappuccio,Christine Cavalcanti-Proença,Christine Cavalcanti-Proença,Yii-Der Ida Chen,Chih-Mei Chen,Peter S. Chines,Robert Clarke,Lachlan J. M. Coin,John M. C. Connell,Ian N. M. Day,Martin den Heijer,Jubao Duan,Shah Ebrahim,Paul Elliott,Roberto Elosua,Gudny Eiriksdottir,Michael R. Erdos,Johan G. Eriksson,Maurizio F. Facheris,Stephan B. Felix,Pamela Fischer-Posovszky,Aaron R. Folsom,Aaron R. Folsom,Nele Friedrich,Nelson B. Freimer,Mao Fu,Stefan Gaget,Stefan Gaget,Pablo V. Gejman,Eco J. C. de Geus,Christian Gieger,Anette P. Gjesing,Anuj Goel,Philippe Goyette,Harald Grallert,Juergen Graessler,Danielle M. Greenawalt,Christopher J. Groves,Vilmundur Gudnason,Candace Guiducci,Anna-Liisa Hartikainen,Neelam Hassanali,Alistair S. Hall,Aki S. Havulinna,Caroline Hayward,Andrew C. Heath,Christian Hengstenberg,Andrew A. Hicks,Anke Hinney,Albert Hofman,Georg Homuth,Jennie Hui,Wilmar Igl,Carlos Iribarren,Carlos Iribarren,Bo Isomaa,Kevin B. Jacobs,Ivonne Jarick,Elizabeth S. Jewell,Ulrich John,Torben Jørgensen,Pekka Jousilahti,Antti Jula,Marika Kaakinen,Eero Kajantie,Lee M. Kaplan,Sekar Kathiresan,Johannes Kettunen,Leena Kinnunen,Joshua W. Knowles,Ivana Kolcic,Inke R. Koenig,Seppo Koskinen,Peter Kovacs,Johanna Kuusisto,Peter Kraft,Kirsti Kvaløy,Jaana Laitinen,Olivier Lantieri,Chiara Lanzani,Lenore J. Launer,Cécile Lecoeur,Cécile Lecoeur,Terho Lehtimaeki,Guillaume Lettre,Guillaume Lettre,Jianjun Liu,Marja-Liisa Lokki,Mattias Lorentzon,Robert Luben,Barbara Ludwig,Paolo Manunta,Diana Marek,Michel Marre,Nicholas G. Martin,Wendy L. McArdle,Anne McCarthy,Barbara McKnight,Thomas Meitinger,Olle Melander,David Meyre,David Meyre,Kristian Midthjell,Grant W. Montgomery,Mario A. Morken,Andrew P. Morris,Rosanda Mulić,Julius S. Ngwa,Mari Nelis,Mari Nelis,Matt Neville,Dale R. Nyholt,Christopher J. O'Donnell,Stephen O'Rahilly,Ken K. Ong,Ben A. Oostra,Guillaume Paré,Alex N. Parker,Markus Perola,Irene Pichler,Kirsi H. Pietilaeinen,Carl G. P. Platou,Ozren Polasek,Anneli Pouta,Suzanne Rafelt,Olli T. Raitakari,Nigel W. Rayner,Martin Ridderstråle,Winfried Rief,Aimo Ruokonen,Neil Robertson,Peter Rzehak,Veikko Salomaa,Alan R. Sanders,Manjinder S. Sandhu,Manjinder S. Sandhu,Serena Sanna,Jouko Saramies,Markku J. Savolainen,Susann Scherag,Sabine Schipf,Stefan Schreiber,Heribert Schunkert,Kaisa Silander,Juha Sinisalo,David S. Siscovick,Jan Smit,Nicole Soranzo,Nicole Soranzo,Ulla Sovio,Jonathan Stephens,Jonathan Stephens,Ida Surakka,Amy J. Swift,Mari-Liis Tammesoo,Jean-Claude Tardif,Jean-Claude Tardif,Maris Teder-Laving,Tanya M. Teslovich,John R. Thompson,John R. Thompson,Brian Thomson,Anke Toenjes,Tiinamaija Tuomi,Joyce B. J. van Meurs,Gert-Jan B. van Ommen,Vincent Vatin,Vincent Vatin,Jorma S. A. Viikari,Jorma S. A. Viikari,Sophie Visvikis-Siest,Veronique Vitart,Carla I. G. Vogel,Benjamin F. Voight,Lindsay L. Waite,Henri Wallaschofski,G. Bragi Walters,Elisabeth Widen,Susanna Wiegand,Sarah H. Wild,Gonneke Willemsen,Daniel R. Witte,Jacqueline C. M. Witteman,Jianfeng Xu,Qunyuan Zhang,Lina Zgaga,Andreas Ziegler,Paavo Zitting,John Beilby,I. Sadaf Farooqi,Johannes Hebebrand,Heikki V. Huikuri,Alan James,Mika Kaehoenen,Douglas F. Levinson,Fabio Macciardi,Fabio Macciardi,Markku S. Nieminen,Claes Ohlsson,Lyle J. Palmer,Paul M. Ridker,Paul M. Ridker,Michael Stumvoll,Jacques S. Beckmann,Heiner Boeing,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Stephen J. Chanock,Francis S. Collins,L. Adrienne Cupples,George Davey Smith,Jeanette Erdmann,Philippe Froguel,Philippe Froguel,Philippe Froguel,Henrik Greonberg,Ulf Gyllensten,Per Hall,Torben Hansen,Tamara B. Harris,Andrew T. Hattersley,Richard B. Hayes,Joachim Heinrich,Frank B. Hu,Frank B. Hu,Kristian Hveem,Thomas Illig,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Jaakko Kaprio,Fredrik Karpe,Kay-Tee Khaw,Lambertus A. Kiemeney,Heiko Krude,Markku Laakso,Debbie A Lawlor,Andres Metspalu,Patricia B. Munroe,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Oluf Pedersen,Oluf Pedersen,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Annette Peters,Peter P. Pramstaller,Thomas Quertermous,Thomas Reinehr,Aila Rissanen,Igor Rudan,Igor Rudan,Nilesh J. Samani,Peter Schwarz,Alan R. Shuldiner,Tim D. Spector,Jaakko Tuomilehto,Manuela Uda,André G. Uitterlinden,Timo T. Valle,Martin Wabitsch,Gerard Waeber,Nicholas J. Wareham,Hugh Watkins,James F. Wilson,Alan F. Wright,M. Carola Zillikens,Nilanjan Chatterjee,Steven A. McCarroll,Shaun Purcell,Eric E. Schadt,Peter M. Visscher,Themistocles L. Assimes,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Leif Groop,Talin Haritunians,David J. Hunter,David J. Hunter,Robert C. Kaplan,Karen L. Mohlke,Jeffrey R. O'Connell,Leena Peltonen,David Schlessinger,David P. Strachan,Cornelia M. van Duijn,H-Erich Wichmann,Timothy M. Frayling,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Gonçalo R. Abecasis,Inês Barroso,Inês Barroso,Michael Boehnke,Kari Stefansson,Kari Stefansson,Kari E. North,Mark I. McCarthy,Joel N. Hirschhorn,Erik Ingelsson,Ruth J. F. Loos +413 more
TL;DR: Genetic loci associated with body mass index map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor, which may provide new insights into human body weight regulation.
Defining the role of common variation in the genomic and biological architecture of adult human height
Andrew R. Wood,Tõnu Esko,Jian Yang,Sailaja Vedantam,Tune H. Pers,Stefan Gustafsson,Audrey Y. Chu,K. Estrada,Jian'an Luan,Zoltán Kutalik,Najaf Amin,Martin L. Buchkovich,Damien C. Croteau-Chonka,Felix R. Day,Yanan Duan,Tove Fall,Rudolf S N Fehrmann,Teresa Ferreira,Anne U. Jackson,Juha Karjalainen,Ken Sin Lo,Adam E. Locke,Reedik Mägi,Evelin Mihailov,Eleonora Porcu,Joshua C. Randall,André Scherag,Anna A. E. Vinkhuyzen,Harm-Jan Westra,Thomas W. Winkler,Tsegaselassie Workalemahu,Jing Hua Zhao,Devin Absher,Eva Albrecht,Denise Anderson,Jeffrey Baron,Marian Beekman,Ayse Demirkan,Georg Ehret,Bjarke Feenstra,Mary F. Feitosa,Krista Fischer,Ross M. Fraser,Anuj Goel,Jian Gong,Anne E. Justice,Stavroula Kanoni,Marcus E. Kleber,K. Kristiansson,Unhee Lim,Vaneet Lotay,Julian C. Lui,Massimo Mangino,Irene Mateo Leach,Carolina Medina-Gomez,Mike A. Nalls,Dale R. Nyholt,Cameron D. Palmer,Dorota Pasko,Sonali Pechlivanis,Inga Prokopenko,Janina S. Ried,Stephan Ripke,Dmitry Shungin,Alena Stančáková,Rona J. Strawbridge,Yun Ju Sung,Toshiko Tanaka,Alexander Teumer,Stella Trompet,Sander W. van der Laan,Jessica van Setten,Jana V. van Vliet-Ostaptchouk,Zhaoming Wang,Loic Yengo,Weihua Zhang,Uzma Afzal,Johan Ärnlöv,Gillian M. Arscott,Stefania Bandinelli,Amy Barrett,Claire Bellis,Amanda J. Bennett,Christian Berne,Matthias Blüher,Jennifer L. Bolton,Yvonne Böttcher,Heather A. Boyd,Marcel Bruinenberg,Brendan M. Buckley,Steven Buyske,Ida Henriette Caspersen,Peter S. Chines,Robert Clarke,Simone Claudi-Boehm,Mark E. Cooper,E. Warwick Daw,Pim A. de Jong,Joris Deelen,Graciela Delgado,Josh C. Denny,Rosalie A.M. Dhonukshe-Rutten,Maria Dimitriou,Alex S. F. Doney,Marcus Dörr,Niina Eklund,Elodie Eury,Lasse Folkersen,Melissa E. Garcia,Frank Geller,Vilmantas Giedraitis,Alan S. Go,Harald Grallert,Tanja B. Grammer,Jürgen Gräßler,Henrik Grönberg,Lisette C P G M de Groot,C J Groves,Jeffrey Haessler,Per Hall,T. Haller,Göran Hallmans,Anke Hannemann,Catharina A. Hartman,Maija Hassinen,Caroline Hayward,Nancy L. Heard-Costa,Quinta Helmer,Gibran Hemani,Anjali K. Henders,Hans L. Hillege,Mark A. Hlatky,Wolfgang Hoffmann,Per Hoffmann,Oddgeir L. Holmen,Jeanine J. Houwing-Duistermaat,Thomas Illig,Aaron Isaacs,Alan L. James,Janina M. Jeff,Berit Johansen,Åsa Johansson,Jennifer Jolley,Thorhildur Juliusdottir,Juhani Junttila,Abel N. Kho,Leena Kinnunen,Norman Klopp,Thomas Kocher,Wolfgang Kratzer,Peter Lichtner,Lars Lind,Jaana Lindström,Stéphane Lobbens,Mattias Lorentzon,Yingchang Lu,Valeriya Lyssenko,Patrik K. E. Magnusson,Anubha Mahajan,Marc R. Maillard,Wendy L. McArdle,Colin A. McKenzie,Stela McLachlan,Paul J. McLaren,Cristina Menni,Sigrun Merger,Lili Milani,Alireza Moayyeri,Keri L. Monda,M. A. Morken,Gabriele Müller,Martina Müller-Nurasyid,A.W. Musk,Narisu Narisu,Matthias Nauck,Ilja M. Nolte,Markus M. Nöthen,Laticia Oozageer,Stefan Pilz,Nigel W. Rayner,Frida Renström,Neil R. Robertson,Lynda M. Rose,Ronan Roussel,Serena Sanna,Hubert Scharnagl,Salome Scholtens,Fredrick R. Schumacher,Heribert Schunkert,Robert A. Scott,J Sehmi,Thomas Seufferlein,Jianxin Shi,Karri Silventoinen,Johannes H. Smit,Albert V. Smith,Joanna Smolonska,Alice V. Stanton,Kathleen Stirrups,David J. Stott,Heather M. Stringham,Johan Sundström,Morris A. Swertz,Ann-Christine Syvänen,Bamidele O. Tayo,Gudmar Thorleifsson,Jonathan P. Tyrer,Suzanne C. van Dijk,Natasja M. van Schoor,Nathalie van der Velde,Diana van Heemst,Floor V. A. van Oort,S. H. H. M. Vermeulen,Niek Verweij,Judith M. Vonk,Lindsay L. Waite,Melanie Waldenberger,Roman Wennauer,Lynne R. Wilkens,Christina Willenborg,Tom Wilsgaard,Mary K. Wojczynski,Andrew Wong,Alan F. Wright,Qunyuan Zhang,Dominique Arveiler,Stephan J. L. Bakker,John Beilby,Richard N. Bergman,Sven Bergmann,Reiner Biffar,John Blangero,Dorret I. Boomsma,Stefan R. Bornstein,Pascal Bovet,Paolo Brambilla,Morris J. Brown,Harry Campbell,Mark J. Caulfield,Aravinda Chakravarti,Rory Collins,Francis S. Collins,Dana C. Crawford,L. Adrienne Cupples,John Danesh,Ulf de Faire,Hester M. den Ruijter,Raimund Erbel,Jeanette Erdmann,Johan G. Eriksson,Martin Farrall,Ele Ferrannini,Jean Ferrières,Ian Ford,Nita G. Forouhi,Terrence Forrester,Ron T. Gansevoort,Pablo V. Gejman,Christian Gieger,Alain Golay,Omri Gottesman,Vilmundur Gudnason,Ulf Gyllensten,David W. Haas,Alistair S. Hall,Tamara B. Harris,Andrew T. Hattersley,Andrew C. Heath,Christian Hengstenberg,Andrew A. Hicks,Lucia A. Hindorff,Aroon D. Hingorani,Albert Hofman,G. Kees Hovingh,Steve E. Humphries,Steven C. Hunt,Elina Hyppönen,Kevin B. Jacobs,Marjo-Riitta Järvelin,Pekka Jousilahti,Antti Jula,Jaakko Kaprio,John J. P. Kastelein,Manfred Kayser,Frank Kee,Keinänen-Kiukaanniemi S,Lambertus A. Kiemeney,Jaspal S. Kooner,Charles Kooperberg,Seppo Koskinen,Peter Kovacs,Aldi T. Kraja,Meena Kumari,Johanna Kuusisto,Timo A. Lakka,Claudia Langenberg,Loic Le Marchand,Terho Lehtimäki,Sara Lupoli,Pamela A. F. Madden,Satu Männistö,Paolo Manunta,Andre Marette,Tara C. Matise,Barbara McKnight,Thomas Meitinger,Frans L. Moll,Grant W. Montgomery,Andrew D. Morris,Andrew P. Morris,Jeffrey C. Murray,Mari Nelis,Claes Ohlsson,Albertine J. Oldehinkel,Ken K. Ong,Willem H. Ouwehand,Gerard Pasterkamp,Annette Peters,Peter P. Pramstaller,Jackie F. Price,Lu Qi,Olli T. Raitakari,Tuomo Rankinen,Dabeeru C. Rao,Treva Rice,Marylyn D. Ritchie,Igor Rudan,Veikko Salomaa,Nilesh J. Samani,Jouko Saramies,Mark A. Sarzynski,Peter E. H. Schwarz,Sylvain Sebert,Peter S. Sever,Alan R. Shuldiner,Juha Sinisalo,Valgerdur Steinthorsdottir,Ronald P. Stolk,Jean-Claude Tardif,A Tönjes,Angelo Tremblay,Elena Tremoli,Jarmo Virtamo,Marie-Claude Vohl,Philippe Amouyel,Folkert W. Asselbergs,Themistocles L. Assimes,Murielle Bochud,Bernhard O. Boehm,Eric Boerwinkle,Erwin P. Bottinger,Claude Bouchard,Stéphane Cauchi,John C. Chambers,Stephen J. Chanock,Richard S. Cooper,Paul I.W. de Bakker,George Dedoussis,Luigi Ferrucci,Paul W. Franks,Philippe Froguel,Leif Groop,Christopher A. Haiman,Anders Hamsten,M. Geoffrey Hayes,Jennie Hui,David J. Hunter,Kristian Hveem,J. Wouter Jukema,Robert C. Kaplan,Mika Kivimäki,Diana Kuh,Markku Laakso,Yongmei Liu,Nicholas G. Martin,Winfried März,Mads Melbye,Susanne Moebus,Patricia B. Munroe,Inger Njølstad,Ben A. Oostra,Colin N. A. Palmer,Nancy L. Pedersen,Markus Perola,Louis Pérusse,Ulrike Peters,Joseph E. Powell,Chris Power,Thomas Quertermous,Rainer Rauramaa,Eva Reinmaa,Paul M. Ridker,Fernando Rivadeneira,Jerome I. Rotter,T. Saaristo,Danish Saleheen,David Schlessinger,P. Eline Slagboom,Harold Snieder,Tim D. Spector,Konstantin Strauch,Michael Stumvoll,Jaakko Tuomilehto,Matti Uusitupa,Pim van der Harst,Henry Völzke,Mark Walker,Nicholas J. Wareham,Hugh Watkins,H.-Erich Wichmann,James F. Wilson,Pieter Zanen,Panos Deloukas,Iris M. Heid,Cecilia M. Lindgren,Karen L. Mohlke,Elizabeth K. Speliotes,Unnur Thorsteinsdottir,Inês Barroso,Caroline S. Fox,Kari E. North,David P. Strachan,Jacques S. Beckmann,Sonja I. Berndt,Michael Boehnke,Ingrid B. Borecki,Mark I. McCarthy,Andres Metspalu,Kari Stefansson,André G. Uitterlinden,Cornelia M. van Duijn,Lude Franke,Cristen J. Willer,Alkes L. Price,Guillaume Lettre,Ruth J. F. Loos,Michael N. Weedon,Erik Ingelsson,Jeffrey R. O'Connell,Gonçalo R. Abecasis,Daniel I. Chasman,Michael E. Goddard,Peter M. Visscher,Joel N. Hirschhorn,Timothy M. Frayling +444 more
TL;DR: This article identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height, and all common variants together captured 60% of heritability.
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Sonja I. Berndt,Stefan Gustafsson,Stefan Gustafsson,Reedik Mägi,Reedik Mägi,Andrea Ganna,Eleanor Wheeler,Mary F. Feitosa,Anne E. Justice,Keri L. Monda,Keri L. Monda,Damien C. Croteau-Chonka,Felix R. Day,Tõnu Esko,Tove Fall,Teresa Ferreira,Davide Gentilini,Anne U. Jackson,Jian'an Luan,Joshua C. Randall,Joshua C. Randall,Sailaja Vedantam,Sailaja Vedantam,Sailaja Vedantam,Cristen J. Willer,Thomas W. Winkler,Andrew R. Wood,Tsegaselassie Workalemahu,Tsegaselassie Workalemahu,Yi-Juan Hu,Sang Hong Lee,Liming Liang,Danyu Lin,Josine L. Min,Benjamin M. Neale,Gudmar Thorleifsson,Jian Yang,Jian Yang,Eva Albrecht,Najaf Amin,Jennifer L. Bragg-Gresham,Gemma Cadby,Gemma Cadby,Martin den Heijer,Niina Eklund,Krista Fischer,Anuj Goel,Jouke-Jan Hottenga,Jennifer E. Huffman,Ivonne Jarick,Åsa Johansson,Åsa Johansson,Toby Johnson,Stavroula Kanoni,Marcus E. Kleber,Inke R. König,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Claudia Lamina,Cécile Lecoeur,Cécile Lecoeur,Guo Li,Massimo Mangino,Wendy L. McArdle,Carolina Medina-Gomez,Martina Müller-Nurasyid,Julius S. Ngwa,Ilja M. Nolte,Lavinia Paternoster,Sonali Pechlivanis,Markus Perola,Markus Perola,Markus Perola,Marjolein J. Peters,Michael Preuss,Lynda M. Rose,Jianxin Shi,Dmitry Shungin,Dmitry Shungin,Albert V. Smith,Rona J. Strawbridge,Ida Surakka,Ida Surakka,Alexander Teumer,Mieke D. Trip,Jonathan Tyrer,Jana V. van Vliet-Ostaptchouk,Liesbeth Vandenput,Lindsay L. Waite,Jing Hua Zhao,Devin Absher,Folkert W. Asselbergs,Mustafa Atalay,Antony P. Attwood,Anthony J. Balmforth,Hanneke Basart,John Beilby,Lori L. Bonnycastle,Paolo Brambilla,Marcel Bruinenberg,Harry Campbell,Daniel I. Chasman,Daniel I. Chasman,Peter S. Chines,Francis S. Collins,John M. C. Connell,John M. C. Connell,William O.C.M. Cookson,Ulf de Faire,Femmie de Vegt,Mariano Dei,Maria Dimitriou,Sarah Edkins,Karol Estrada,David M. Evans,Martin Farrall,Marco M Ferrario,Jean Ferrières,Lude Franke,Francesca Frau,Pablo V. Gejman,Pablo V. Gejman,Harald Grallert,Henrik Grönberg,Vilmundur Gudnason,Alistair S. Hall,Per Hall,Anna-Liisa Hartikainen,Caroline Hayward,Nancy L. Heard-Costa,Andrew C. Heath,Johannes Hebebrand,Georg Homuth,Frank B. Hu,Sarah E. Hunt,Elina Hyppönen,Carlos Iribarren,Kevin B. Jacobs,Kevin B. Jacobs,John-Olov Jansson,Antti Jula,Mika Kähönen,Sekar Kathiresan,Frank Kee,Kay-Tee Khaw,Mika Kivimäki,Wolfgang Koenig,Aldi T. Kraja,Meena Kumari,Kari Kuulasmaa,Johanna Kuusisto,Jaana Laitinen,Timo A. Lakka,Claudia Langenberg,Claudia Langenberg,Lenore J. Launer,Lars Lind,Jaana Lindström,Jianjun Liu,Antonio Liuzzi,Marja-Liisa Lokki,Mattias Lorentzon,Pamela A. F. Madden,Patrik K. E. Magnusson,Paolo Manunta,Diana Marek,Diana Marek,Winfried März,Winfried März,Irene Mateo Leach,Barbara McKnight,Sarah E. Medland,Evelin Mihailov,Lili Milani,Grant W. Montgomery,Vincent Mooser,Thomas W. Mühleisen,Patricia B. Munroe,Arthur W. Musk,Arthur W. Musk,Narisu Narisu,Gerjan Navis,George Nicholson,Ellen A. Nohr,Ken K. Ong,Ben A. Oostra,Ben A. Oostra,Colin N. A. Palmer,Aarno Palotie,Aarno Palotie,John F. Peden,Nancy L. Pedersen,Annette Peters,Ozren Polasek,Anneli Pouta,Anneli Pouta,Peter P. Pramstaller,Inga Prokopenko,Inga Prokopenko,Carolin Pütter,Aparna Radhakrishnan,Aparna Radhakrishnan,Aparna Radhakrishnan,Olli T. Raitakari,Olli T. Raitakari,Augusto Rendon,Fernando Rivadeneira,Igor Rudan,Timo Saaristo,Jennifer G. Sambrook,Jennifer G. Sambrook,Alan R. Sanders,Alan R. Sanders,Serena Sanna,Jouko Saramies,Sabine Schipf,Stefan Schreiber,Heribert Schunkert,So-Youn Shin,Stefano Signorini,Juha Sinisalo,Boris Skrobek,Boris Skrobek,Nicole Soranzo,Nicole Soranzo,Alena Stančáková,Klaus Stark,Jonathan Stephens,Jonathan Stephens,Kathleen Stirrups,Ronald P. Stolk,Michael Stumvoll,Amy J. Swift,Eirini V. Theodoraki,Barbara Thorand,David-Alexandre Trégouët,Elena Tremoli,Melanie M. van der Klauw,Joyce B. J. van Meurs,Sita H. Vermeulen,Jorma Viikari,Jarmo Virtamo,Veronique Vitart,Gérard Waeber,Zhaoming Wang,Zhaoming Wang,Elisabeth Widen,Sarah H. Wild,Gonneke Willemsen,Bernhard R. Winkelmann,Jacqueline C.M. Witteman,Bruce H. R. Wolffenbuttel,Andrew Wong,Alan F. Wright,M. Carola Zillikens,Philippe Amouyel,Bernhard O. Boehm,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Stephen J. Chanock,L. Adrienne Cupples,Daniele Cusi,George Dedoussis,Jeanette Erdmann,Jeanette Erdmann,Johan G. Eriksson,Johan G. Eriksson,Johan G. Eriksson,Paul W. Franks,Paul W. Franks,Paul W. Franks,Philippe Froguel,Philippe Froguel,Philippe Froguel,Christian Gieger,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Christian Hengstenberg,Andrew A. Hicks,Aroon D. Hingorani,Anke Hinney,Albert Hofman,Kees Hovingh,Kristian Hveem,Thomas Illig,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Sirkka Keinänen-Kiukaanniemi,Sirkka Keinänen-Kiukaanniemi,Lambertus A. Kiemeney,Diana Kuh,Markku Laakso,Terho Lehtimäki,Douglas F. Levinson,Nicholas G. Martin,Andres Metspalu,Andrew D. Morris,Markku S. Nieminen,Inger Njølstad,Claes Ohlsson,Albertine J. Oldehinkel,Willem H. Ouwehand,Lyle J. Palmer,Brenda W.J.H. Penninx,Chris Power,Michael A. Province,Bruce M. Psaty,Lu Qi,Lu Qi,Rainer Rauramaa,Paul M. Ridker,Paul M. Ridker,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Harold Snieder,Thorkild I. A. Sørensen,Tim D. Spector,Kari Stefansson,Kari Stefansson,Anke Tönjes,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,André G. Uitterlinden,Matti Uusitupa,Pim van der Harst,Peter Vollenweider,Henri Wallaschofski,Nicholas J. Wareham,Hugh Watkins,H-Erich Wichmann,James F. Wilson,Gonçalo R. Abecasis,Themistocles L. Assimes,Inês Barroso,Inês Barroso,Michael Boehnke,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Timothy M. Frayling,Leif Groop,Talin Haritunian,Iris M. Heid,David J. Hunter,David J. Hunter,Robert C. Kaplan,Fredrik Karpe,Fredrik Karpe,Miriam F. Moffatt,Karen L. Mohlke,Jeffrey R. O'Connell,Yudi Pawitan,Eric E. Schadt,David Schlessinger,Valgerdur Steinthorsdottir,David P. Strachan,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Cornelia M. van Duijn,Cornelia M. van Duijn,Peter M. Visscher,Anna Maria Di Blasio,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Cecilia M. Lindgren,Andrew P. Morris,David Meyre,David Meyre,David Meyre,André Scherag,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Elizabeth K. Speliotes,Kari E. North,Ruth J. F. Loos,Erik Ingelsson +385 more
TL;DR: A genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry finds a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Sonja I. Berndt,Stefan Gustafsson,Reedik Maegi,Andrea Ganna,Eleanor Wheeler,Mary F. Feitosa,Anne E. Justice,Keri L. Monda,Damien C. Croteau-Chonka,Felix R. Day,Tõnu Esko,Tove Fall,Teresa Ferreira,Davide Gentilini,Anne U. Jackson,Jian'an Luan,Joshua C. Randall,Sailaja Vedantam,Cristen J. Willer,Thomas W. Winkler,Andrew R. Wood,Tsegaselassie Workalemahu,Yi-Juan Hu,Sang Hong Lee,Liming Liang,Danyu Lin,Josine L. Min,Benjamin M. Neale,Gudmar Thorleifsson,Jian Yang,Eva Albrecht,Najaf Amin,Jennifer L. Bragg-Gresham,Gemma Cadby,Martin den Heijer,Niina Eklund,Krista Fischer,Anuj Goel,Jouke-Jan Hottenga,Jennifer E. Huffman,Ivonne Jarick,Åsa Johansson,Toby Johnson,Stavroula Kanoni,Marcus E. Kleber,Inke R. Koenig,Kati Kristiansson,Z. Kutalik,Claudia Lamina,Cécile Lecoeur,Guo Li,Massimo Mangino,Wendy L. McArdle,Carolina Medina-Gomez,Martina Mueller-Nurasyid,Julius S. Ngwa,Ilja M. Nolte,Lavinia Paternoster,Sonali Pechlivanis,Markus Perola,Marjolein Peters,Michael Preuss,Lynda M. Rose,Jianxin Shi,Dmitry Shungin,Albert V. Smith,Rona J. Strawbridge,Ida Surakka,Alexander Teumer,Mieke D. Trip,Jonathan Tyrer,Jana V. van Vliet-Ostaptchouk,Liesbeth Vandenput,Lindsay L. Waite,Jing Hua Zhao,Devin Absher,Folkert W. Asselbergs,Mustafa Atalay,Antony P. Attwood,Anthony J. Balmforth,Hanneke Basart,John Beilby,Lori L. Bonnycastle,Paolo Brambilla,Marcel Bruinenberg,Harry Campbell,Daniel I. Chasman,Peter S. Chines,Francis S. Collins,John M. C. Connell,William O.C.M. Cookson,Ulf de Faire,Femmie de Vegt,Mariano Dei,Maria Dimitriou,Sarah Edkins,Karol Estrada,David M. Evans,Martin Farrall,Marco M Ferrario,Jean Ferrières,Lude Franke,Francesca Frau,Pablo V. Gejman,Harald Grallert,Henrik Groenberg,Vilmundur Gudnason,Alistair S. Hall,Per Hall,Anna-Liisa Hartikainen,Caroline Hayward,Nancy L. Heard-Costa,Andrew Heath,Johannes Hebebrand,Georg Homuth,Frank B. Hu,Sarah E. Hunt,Elina Hyppoenen,Carlos Iribarren,Kevin B. Jacobs,John-Olov Jansson,Antti Jula,Mika Kähönen,Sekar Kathiresan,Frank Kee,Kay-Tee Khaw,Mika Kivimäki,Wolfgang Koenig,Aldi T. Kraja,Meena Kumari,Kari Kuulasmaa,Johanna Kuusisto,Jaana Laitinen,Timo A. Lakka,Claudia Langenberg,Lenore J. Launer,Lars Lind,Jaana Lindström,Jianjun Liu,Antonio Liuzzi,Marja-Liisa Lokki,Mattias Lorentzon,Pamela A. F. Madden,Patrik K. E. Magnusson,Paolo Manunta,Diana Marek,Winfried Maerz,Irene Mateo Leach,Barbara McKnight,Sarah E. Medland,Evelin Mihailov,Lili Milani,Grant W. Montgomery,Vincent Mooser,Thomas W. Muehleisen,Patricia B. Munroe,Arthur W. Musk,Narisu Narisu,Gerjan Navis,George Nicholson,Ellen A. Nohr,Ken K. Ong,Ben A. Oostra,Colin N. A. Palmer,Aarno Palotie,John F. Peden,Nancy L. Pedersen,Annette Peters,Ozren Polasek,Anneli Pouta,Peter P. Pramstaller,Inga Prokopenko,Carolin Puetter,Aparna Radhakrishnan,Olli T. Raitakari,Augusto Rendon,Fernando Rivadeneira,Igor Rudan,Timo Saaristo,Jennifer G. Sambrook,Alan R. Sanders,Serena Sanna,Jouko Saramies,Sabine Schipf,Stefan Schreiber,Heribert Schunkert,So-Youn Shin,Stefano Signorini,Juha Sinisalo,Boris Skrobek,Nicole Soranzo,Alena Stančáková,Klaus Stark,Jonathan Stephens,Kathleen Stirrups,Ronald P. Stolk,Michael Stumvoll,Amy J. Swift,Eirini V. Theodoraki,Barbara Thorand,David-Alexandre Trégouët,Elena Tremoli,Melanie M. van der Klauw,Joyce B. J. van Meurs,Sita H. Vermeulen,Jorma Viikari,Jarmo Virtamo,Veronique Vitart,Gérard Waeber,Zhaoming Wang,Elisabeth Widen,Sarah H. Wild,Gonneke Willemsen,Bernhard R. Winkelmann,Jacqueline C.M. Witteman,Bruce H. R. Wolffenbuttel,Andrew Wong,Alan F. Wright,M. Carola Zillikens,Philippe Amouyel,Bernhard O. Boehm,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Stephen J. Chanock,L. Adrienne Cupples,Daniele Cusi,George Dedoussis,Jeanette Erdmann,Johan G. Eriksson,Paul W. Franks,Philippe Froguel,Christian Gieger,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Christian Hengstenberg,Andrew A. Hicks,Aroon D. Hingorani,Anke Hinney,Albert Hofman,Kees Hovingh,Kristian Hveem,Thomas Illig,Marjo-Riitta Järvelin,Karl-Heinz Joeckel,Sirkka Keinänen-Kiukaanniemi,Lambertus A. Kiemeney,Diana Kuh,Markku Laakso,Terho Lehtimäki,Douglas F. Levinson,Nicholas G. Martin,Andres Metspalu,Andrew D. Morris,Markku S. Nieminen,Inger Njølstad,Claes Ohlsson,Albertine J. Oldehinkel,Willem H. Ouwehand,Lyle J. Palmer,Brenda W.J.H. Penninx,Chris Power,Michael A. Province,Bruce M. Psaty,Lu Qi,Rainer Rauramaa,Paul M. Ridker,Samuli Ripatti,Veikko Salomaa,Nilesh J. Samani,Harold Snieder,Thorkild I. A. Sørensen,Tim D. Spector,Kari Stefansson,Anke Tönjes,Jaakko Tuomilehto,André G. Uitterlinden,Matti Uusitupa,Pim van der Harst,Peter Vollenweider,Henri Wallaschofski,Nicholas J. Wareham,Hugh Watkins,H-Erich Wichmann,James F. Wilson,Gonçalo R. Abecasis,Themistocles L. Assimes,Inês Barroso,Michael Boehnke,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Timothy M. Frayling,Leif Groop,Talin Haritunian,Iris M. Heid,David J. Hunter,Robert C. Kaplan,Fredrik Karpe,Miriam F. Moffatt,Karen L. Mohlke,Jeffrey R. O'Connell,Yudi Pawitan,Eric E. Schadt,David Schlessinger,Valgerdur Steinthorsdottir,David P. Strachan,Unnur Thorsteinsdottir,Cornelia M. van Duijn,Peter M. Visscher,Anna Maria Di Blasio,Joel N. Hirschhorn,Cecilia M. Lindgren,Andrew P. Morris,David Meyre,Andr Scherag,Mark I. McCarthy,Elizabeth K. Speliotes,Kari E. North,Ruth J. F. Loos,Erik Ingelsson +321 more
- 01 Jan 2013
478
Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression
Matteo Trudu,Sylvie Janas,Chiara Lanzani,Huguette Debaix,Huguette Debaix,Céline Schaeffer,Masami Ikehata,Lorena Citterio,Sylvie Demaretz,Francesco Trevisani,Giuseppe Ristagno,Bob Glaudemans,Kamel Laghmani,Giacomo Dell'Antonio,Johannes Loffing,Maria Pia Rastaldi,Paolo Manunta,Olivier Devuyst,Olivier Devuyst,Luca Rampoldi +19 more
TL;DR: The findings point to uromodulin as a therapeutic target for lowering blood pressure and preserving renal function and the relevance of this mechanism in humans is demonstrated by showing that pharmacological inhibition of NKCC2 was more effective in lowering blood pressured patients who are homozygous for UMOD promoter risk variants than in other hypertensive patients.