Michael R. Erdos

TL;DR: In this article, the authors performed systematic chromatin and transcriptome profiling in human pancreatic islets and found that stretch enhancers are critical chromatin elements for coordinating cell type-specific regulatory programs.

TL;DR: The largest integrated analysis to date of high-resolution, high-throughput human islet molecular profiling data is presented to characterize the genome, epigenome, and transcriptome and find that T2D genetic variants are enriched in regions of the genome where transcription Regulatory Factor X (RFX) is predicted to bind in an islet-specific manner.

TL;DR: In this paper, Mendelian randomization (MR) and mediation techniques were used to predict 213 causal relationships between expression and DNA methylation, approximately two-thirds of which predict methylation to causally influence expression.

TL;DR: A proximity-based labeling approach that uses an antibody to a target antigen to guide biotin deposition onto adjacent proteins in fixed cells and primary tissues, which allows proteins in close proximity to the target antigento be captured and identified by mass spectrometry is reported.