Ombretta Caspani
Heidelberg University
10 Papers
3 Citations
Ombretta Caspani is an academic researcher from Heidelberg University. The author has contributed to research in topics: Hyperalgesia & Chronic pain. The author has an hindex of 6, co-authored 10 publications.
Chat about Author
Papers
Human surrogate models of central sensitization: A critical review and practical guide
Charles Quesada,Anna Kostenko,Idy Ho,Caterina Leone,Zahra Nochi,Alexandre Stouffs,Matthias Wittayer,Ombretta Caspani,Nanna B. Finnerup,André Mouraux,Gisèle Pickering,Irene Tracey,Andrea Truini,Rolf-Detlef Treede,Luis Garcia-Larrea +14 more
TL;DR: In this paper, the authors performed a systematic literature review (PubMed-Medline, Cochrane, WoS, ClinicalTrials) and semi-quantitative meta-analysis of human pain models that aim to induce central sensitization, and generate hyperalgesia surrounding a real or simulated injury.
61
Experimental design and reporting standards for improving the internal validity of pre-clinical studies in the field of pain: Consensus of the IMI-Europain consortium
K.L. Knopp,Carina Stenfors,Cathrine Baastrup,A.W. Bannon,Margarita Calvo,Ombretta Caspani,Gillian L. Currie,Nanna B. Finnerup,Wenlong Huang,Jeffrey D. Kennedy,Isabel A Lefevre,Ian Machin,Malcolm R. Macleod,H. Rees,Andrew S.C. Rice,Kris Rutten,M. Segerdahl,Jordi Serra,Rachel Wodarski,O.-G. Berge,Rolf-Detlef Treede +20 more
TL;DR: Members of Europain, a pain research consortium funded by the European Innovative Medicines Initiative, developed internal recommendations on how to improve the reliability of pre-clinical studies between laboratories, focused on two aspects: experimental design and conduct, and study reporting.
28
A comparative behavioural study of mechanical hypersensitivity in 2 pain models in rats and humans.
TL;DR: These data show that rat paw withdrawal threshold to punctate stimuli (0.2 mm diameter) can be used as surrogate parameters for human mechanical pain sensitivity, but probe size and shape should be standardized.
17
IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG).
André Mouraux,Petra Bloms-Funke,Irmgard Boesl,Ombretta Caspani,Sonya C. Chapman,Giulia Di Stefano,Nanna B. Finnerup,Luis Garcia-Larrea,Marcus Goetz,Anna Kostenko,Bernhard Pelz,Esther M. Pogatzki-Zahn,Karin Schubart,Alexandre Stouffs,Andrea Truini,Irene Tracey,Iñaki F. Trocóniz,Johannes Van Niel,Jose Miguel Vela,Katy Vincent,Jan Vollert,Vishvarani Wanigasekera,Matthias Wittayer,Keith G. Phillips,Rolf-Detlef Treede +24 more
TL;DR: The IMI2-PainCare-BioPain-RCT3 clinical trial as discussed by the authors was designed to study the effect of drug exposure and effects of the drug on nociceptive signal processing in human volunteers.
One night of total sleep deprivation promotes a state of generalized hyperalgesia: A surrogate pain model to study the relationship of insomnia and pain
Sigrid Schuh-Hofer,Sigrid Schuh-Hofer,Rachel Wodarski,Doreen B. Pfau,Ombretta Caspani,Walter Magerl,Jeffrey D. Kennedy,Rolf-Detlef Treede +7 more
TL;DR: Findings show that a single night of TSD is able to induce generalized hyperalgesia and to increase State Anxiety scores, and TSD selectively modulated nociception, since detection thresholds of non‐nociceptive modalities remained unchanged.