Neale Harrison
University of Birmingham
17 Papers
7 Citations
Neale Harrison is an academic researcher from University of Birmingham. The author has contributed to research in topics: Tetraspanin & Regeneration (biology). The author has an hindex of 6, co-authored 14 publications. Previous affiliations of Neale Harrison include Scripps Research Institute.
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Papers
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex
Chek Ziu Koo,Chek Ziu Koo,Neale Harrison,Peter J. Noy,Justyna Szyroka,Alexandra L. Matthews,Hung-En Hsia,Stephan A. Mueller,Johanna Tüshaus,Joelle Goulding,Katie Willis,Clara Apicella,Bethany Cragoe,Edward T Davis,Murat Keles,Antonia Malinova,Thomas A. McFarlane,Philip R. Morrison,Hanh T.H. Nguyen,Michael C. Sykes,Haroon Ahmed,Alessandro Di Maio,Lisa Seipold,Paul Saftig,Eleanor Cull,Christos Pliotas,Eric Rubinstein,Natalie S. Poulter,Natalie S. Poulter,Stephen J. Briddon,Nicholas D. Holliday,Stefan F. Lichtenthaler,Michael G. Tomlinson,Michael G. Tomlinson +33 more
TL;DR: An immunogen is designed to generate the first monoclonal antibodies targeting Tspan15, a model TspanC8, and it is shown that endogenous T span15 and ADAM10 co-localize on the cell surface, thatADAM10 is the principal Tspan 15-interacting protein, and that a synthetic ADAM 10/Tspan15 fusion protein is a functional scissor.
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Molecular mechanism of central nervous system repair by the Drosophila NG2 homologue kon-tiki
TL;DR: The NG2-dependent mechanism modulating glial proliferation and differentiation after damage to promote repair, in the central nervous system of Drosophila is identified.
Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential.
TL;DR: In this paper, the authors show that disintegrin and metalloproteinase 10 (ADAM10) interacts with a subgroup of six tetraspanins, termed the TspanC8 subgroup, which are closely related by protein sequence and comprise Tspan5, Tspan10, tspan14, traspanin 14, traspanin 15, trispanin 17, and tspan33.
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An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans
Bryan A Martinez,Pedro Rodrigues,Ricardo M Nuñez Medina,Prosenjit Mondal,Neale Harrison,Museer A Lone,Amanda Webster,Aditi U. Gurkar,Brock Grill,Matthew S. Gill +9 more
TL;DR: A novel, non-signaling isoform of the nematode insulin receptor (IR), DAF-2B, is described that modulates insulin signaling by sequestration of insulin peptides and influences dauer entry, dauer recovery and adult lifespan by altering insulin sensitivity according to the prevailing insulin milieu.
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Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication.
Neale Harrison,Elizabeth Connolly,Alicia Gascón Gubieda,Zidan Yang,Benjamin Altenhein,Maria Losada Perez,Marta Moreira,Jun Sun,Alicia Hidalgo +8 more
TL;DR: In this paper, the authors used Drosophila to search for genes functionally related to the NG2 homologue kon-tiki (kon), and identified Islet Antigen-2 (Ia-2), required in neurons for insulin secretion.
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