Miriam Öttl
5 Papers
Miriam Öttl is an academic researcher. The author has contributed to research in topics: Biology & Proteome. The author has an hindex of 1, co-authored 3 publications.
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Papers
A reference human induced pluripotent stem cell line for large-scale collaborative studies.
Caroline B. Pantazis,Andrian Yang,Erika Lara,Justin A. McDonough,Cornelis Blauwendraat,Li-Zhen Peng,Hideyuki Oguro,Jitendra Kumar Kanaujiya,Jizhong Zou,David P. Sebesta,Gretchen M. Pratt,Erin Cross,Jeffrey Blockwick,Philip C. GlaxoSmithKline Buxton,Lauren B. Kinner-Bibeau,Constance Medura,Christopher Tompkins,Stephen H. Hughes,Marianita Santiana,Faraz Faghri,Mike A. Nalls,Dan Vitale,Shannon Ballard,Yue Qi,Daniel M. Ramos,Kailyn Anderson,Julia Stadler,Priyanka Narayan,Jason Papademetriou,Luke Reilly,Matthew Nelson,Sanya Aggarwal,Leah U. Rosen,Peter Kirwan,Venkat Pisupati,Steven L. Coon,Sonja W. Scholz,Theresa Priebe,Miriam Öttl,Jian Dong,Marieke Meijer,Lara Janssen,Vanessa S. Lourenço,Rik van der Kant,Dennis Crusius,Dominik Paquet,Ana-Caroline Raulin,Guojun Bu,Aaron Held,Brian J. Wainger,Rebecca Gabriele,Jackie M. Casey,Selina Wray,Dad Abu-Bonsrah,Clare L. Parish,Melinda S. Beccari,Don W. Cleveland,Emmy Li,Indigo V.L. Rose,Martin Kampmann,Carles Calatayud Aristoy,Patrik Verstreken,Laurin Heinrich,M.-Y. Chen,Birgitt Schüle,Dan Dou,Erika L.F. Holzbaur,Maria C. Zanellati,Richa Basundra,Mohanish Deshmukh,Sarah Cohen,Richa Khanna,Malavika Raman,Zachary S. Nevin,Madeline Matia,J B Van Lent,Vincent Timmerman,Bruce R. Conklin,Katherine Johnson Chase,Ke Zhang,Salome Funes,Daryl A. Bosco,Lena Erlebach,Marc Welzer,Deborah Kronenberg-Versteeg,Guochang Lyu,Ernest Arenas,Elena Coccia,Lily Sarrafha,Tim Ahfeldt,John C. Marioni,William C. Skarnes,Mark R. Cookson,Michael E. Ward,Florian T. Merkle +94 more
TL;DR: KOLF2.1J as discussed by the authors is an all-around well-performing human induced pluripotent stem cell (iPSC) line and has been shown to have good performance in head-to-head comparisons with their own preferred iPSC lines across a diverse range of differentiation protocols and functional assays.
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Reduced MUNC18-1 levels, synaptic proteome changes and altered network activity in STXBP1-related disorder patient neurons
Annemiek A. van Berkel,Miriam Öttl,Frank Koopmans,Mala Misra-lsrie,Marieke Meijer,Robertino Dilena,Peter M. van Hasselt,Mieke M. van Haelst,August B. Smit,Sophie van der Sluis,Ruud F. Toonen,Matthijs Verhage +11 more
TL;DR: In this paper , the authors combined live-cell imaging, electrophysiology, confocal microscopy and mass spec proteomics to characterize cellular phenotypes of iPSC-derived neurons from six STXBP1-RD patients, capturing shared features as well as phenotypic diversity among patients.
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Reduced synaptic depression in human neurons carrying homozygous disease-causing STXBP1 variant L446F.
TL;DR: Reduced synaptic depression in human neurons carrying homozygous disease-causing STXBP1 variant L446F.
Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes
Marieke Meijer,Miriam Öttl,Jie Yang,Aygul Subkhangulova,Avinash Kumar,Zicheng Feng,T. V. van Voorst,Alexander J. Groffen,Jan R.T. van Weering,Yongli Zhang,Matthijs Verhage +10 more
TL;DR: Tomosyns regulate synaptic transmission by binding to VAMP2-containing template complexes, preventing SNAP-25 association and limiting initial synaptic strength, rather than competing with VAMP2 for SNARE assembly as previously thought.
Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes
Marieke Meijer,Miriam Öttl,Jie Yang,Aygul Subkhangulova,Avinash Kumar,Alexander J. Groffen,Jan R.T. van Weering,Yongli Zhang,Matthijs Verhage +8 more
TL;DR: This article showed that tomosyn-1/2 deficiency drastically increased the probability that synaptic vesicles fuse at synapses, resulting in stronger synapses with faster depression and slower recovery.