Marc Welzer
German Center for Neurodegenerative Diseases
5 Papers
Marc Welzer is an academic researcher from German Center for Neurodegenerative Diseases. The author has contributed to research in topics: Slice preparation & Induced pluripotent stem cell. The author has an hindex of 2, co-authored 2 publications. Previous affiliations of Marc Welzer include University of Tübingen.
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Papers
A reference human induced pluripotent stem cell line for large-scale collaborative studies.
Caroline B. Pantazis,Andrian Yang,Erika Lara,Justin A. McDonough,Cornelis Blauwendraat,Li-Zhen Peng,Hideyuki Oguro,Jitendra Kumar Kanaujiya,Jizhong Zou,David P. Sebesta,Gretchen M. Pratt,Erin Cross,Jeffrey Blockwick,Philip C. GlaxoSmithKline Buxton,Lauren B. Kinner-Bibeau,Constance Medura,Christopher Tompkins,Stephen H. Hughes,Marianita Santiana,Faraz Faghri,Mike A. Nalls,Dan Vitale,Shannon Ballard,Yue Qi,Daniel M. Ramos,Kailyn Anderson,Julia Stadler,Priyanka Narayan,Jason Papademetriou,Luke Reilly,Matthew Nelson,Sanya Aggarwal,Leah U. Rosen,Peter Kirwan,Venkat Pisupati,Steven L. Coon,Sonja W. Scholz,Theresa Priebe,Miriam Öttl,Jian Dong,Marieke Meijer,Lara Janssen,Vanessa S. Lourenço,Rik van der Kant,Dennis Crusius,Dominik Paquet,Ana-Caroline Raulin,Guojun Bu,Aaron Held,Brian J. Wainger,Rebecca Gabriele,Jackie M. Casey,Selina Wray,Dad Abu-Bonsrah,Clare L. Parish,Melinda S. Beccari,Don W. Cleveland,Emmy Li,Indigo V.L. Rose,Martin Kampmann,Carles Calatayud Aristoy,Patrik Verstreken,Laurin Heinrich,M.-Y. Chen,Birgitt Schüle,Dan Dou,Erika L.F. Holzbaur,Maria C. Zanellati,Richa Basundra,Mohanish Deshmukh,Sarah Cohen,Richa Khanna,Malavika Raman,Zachary S. Nevin,Madeline Matia,J B Van Lent,Vincent Timmerman,Bruce R. Conklin,Katherine Johnson Chase,Ke Zhang,Salome Funes,Daryl A. Bosco,Lena Erlebach,Marc Welzer,Deborah Kronenberg-Versteeg,Guochang Lyu,Ernest Arenas,Elena Coccia,Lily Sarrafha,Tim Ahfeldt,John C. Marioni,William C. Skarnes,Mark R. Cookson,Michael E. Ward,Florian T. Merkle +94 more
TL;DR: KOLF2.1J as discussed by the authors is an all-around well-performing human induced pluripotent stem cell (iPSC) line and has been shown to have good performance in head-to-head comparisons with their own preferred iPSC lines across a diverse range of differentiation protocols and functional assays.
147
Long-term adult human brain slice cultures as a model system to study human CNS circuitry and disease
Niklas Schwarz,Betül Uysal,Marc Welzer,Marc Welzer,Jacqueline C Bahr,Nikolas Layer,Heidi Löffler,Kornelijus Stanaitis,Harshad Pa,Yvonne G. Weber,Ulrike B. S. Hedrich,Jürgen Honegger,Angelos Skodras,Angelos Skodras,Albert J. Becker,Thomas V. Wuttke,Henner Koch +16 more
TL;DR: Robust preservation of the complex neuronal cytoarchitecture and electrophysiological properties of human pyramidal neurons in long-term brain slice cultures is demonstrated in a model system suitable for therapeutic screening and genetic dissection of human CNS circuitry.
91
Chimeric human organoid and mouse brain slice co-cultures to study microglial function.
Vasiliki Panagiotakopoulou,Marc Welzer,Olmo Ruiz Ormaechea,Diana Werner,Lena Erlebach,Anika Bühler,Ulrike Obermüller,Jonas J. Neher,Mathias Jucker,Deborah Kronenberg‐Versteeg +9 more
Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures.
Melanie Barth,Melanie Barth,Mehtap Bacioglu,Mehtap Bacioglu,Niklas Schwarz,Renata Novotny,Renata Novotny,Janine Brandes,Marc Welzer,Marc Welzer,Sonia Mazzitelli,Sonia Mazzitelli,Lisa M. Häsler,Lisa M. Häsler,Manuel Schweighauser,Manuel Schweighauser,Thomas V. Wuttke,Deborah Kronenberg-Versteeg,Deborah Kronenberg-Versteeg,Karina Fog,Malene Ambjørn,Ania Alik,Ronald Melki,Philipp J. Kahle,Philipp J. Kahle,Derya R. Shimshek,Henner Koch,Henner Koch,Mathias Jucker,Mathias Jucker,Gaye Tanriöver,Gaye Tanriöver +31 more
TL;DR: The successful translation of these brain cultures from mouse to human with the first reported induction of human αS lesions in a true adult human brain environment underlines the potential of this model to study proteopathic lesions in intact mouse and now even aged human brain environments.
New in vitro tools to investigate the role of microglia in neurodegeneration
Lena Erlebach,Marc Welzer,Anika Bühler,Daniela Miely,Niklas Schwarz,Vasiliki Panagiotakopoulou,Lisa M. Haesler,Marius Lambert,Ulrike Obermüller,Natalie Beschorner,Henner Koch,Jonas J. Neher,Thomas Wuttke,Ulrike Hedrich‐Klimosch,Mathias Jucker,Deborah Kronenberg‐Versteeg +15 more
- 01 Dec 2023
TL;DR: Human induced pluripotent stem cells have transpired as an attractive tool to investigate neurological diseases, but it remains a challenge to fully recapitulate an in vivo‐like phenotype ex vivo.