Martina Kerndl
Washington University in St. Louis
6 Papers
Martina Kerndl is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Biology & Immunology. The author has an hindex of 2, co-authored 2 publications.
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Papers
Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging
Denis A. Mogilenko,Oleg Shpynov,Oleg Shpynov,Prabhakar S. Andhey,Laura L. Arthur,Amanda Swain,Ekaterina Esaulova,Simone Brioschi,Irina Shchukina,Martina Kerndl,Monika Bambouskova,Zhangting Yao,Anwesha Laha,Konstantin Zaitsev,Samantha Burdess,Susan Gillfilan,Sheila A. Stewart,Marco Colonna,Maxim N. Artyomov +18 more
TL;DR: This work defined organ-specific and common immune alterations and identified a subpopulation of age-associated granzyme K-expressing CD8+ T (Taa) cells that are distinct from T effector memory (Tem) cells, a potential target to address age- associated dysfunctions of the immune system.
431
Itaconate confers tolerance to late NLRP3 inflammasome activation
Monika Bambouskova,Lucie Potuckova,Tomas Paulenda,Martina Kerndl,Denis A. Mogilenko,Kate Lizotte,Amanda Swain,Sebastian Hayes,Ryan D. Sheldon,Hyeryun Kim,Unnati Kapadnis,Abigail E. Ellis,Christine Isaguirre,Samantha Burdess,Anwesha Laha,Gaya K. Amarasinghe,Victor Chubukov,Thomas P. Roddy,Michael S. Diamond,Russell G. Jones,Donald M. Simons,Maxim N. Artyomov +21 more
TL;DR: Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR) stimulation in myeloid cells, and it is shown that itaconate acts synergistically with inducible nitric oxide synthase (iNOS) and that the ability of various TLR ligands to establish NLRP3 inflammasome tolerance depends on the pattern of co-expression of IRG1 and iNOS as discussed by the authors.
151
Deep MALDI-MS spatial omics guided by quantum cascade laser mid-infrared imaging microscopy
Lars Gruber,Stefan Schmidt,Thomas Enzlein,Huong Giang Vo,Tobias Bausbacher,James L. Cairns,Yasemin Ucal,Florian Keller,Martina Kerndl,D. A. Sammour,Omar Sharif,Gernot Schabbauer,Rüdiger Rudolf,Matthias Eckhardt,Stefania Alexandra Iakab,L. Bindila,Carsten Hopf +16 more
TL;DR: Researchers developed a fast, label-free imaging technique using quantum cascade laser mid-infrared microscopy to guide mass spectrometry imaging, enabling confident molecular identification and in-depth lipid analysis in complex tissues, such as kidney glomeruli and spinal cord lesions.
5
Protocol to assess the tolerogenic properties of adoptively transferred dendritic cells during murine experimental autoimmune encephalomyelitis
TL;DR: Vogel et al. as discussed by the authors described how to determine the tolerogenic capacities of dendritic cells in the context of the experimental autoimmune encephalomyelitis (EAE).
3
PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis
Mario Kuttke,Dominika Hromadová,Ceren Yildirim,Julia S. Brunner,Andrea Vogel,Hannah Paar,Sophie Peters,Martina Weber,Melanie Hofmann,Martina Kerndl,Markus Kieler,Hannes Datler,Laszlo Musiejovsky,Manuel Salzmann,Michaela Lang,Klara Soukup,Angela Halfmann,Omar Sharif,Gernot Schabbauer +18 more
TL;DR: It is reported that the PI3K/PTEN signaling pathway in dendritic cells enhances IL-6 production in a model of DSS-induced colitis, which results in exacerbated Th1 cell responses and increased mortality in DC-specific PTEN knockout (PTENΔDC) animals.