Marion Muche
Charité
19 Papers
34 Citations
Marion Muche is an academic researcher from Charité. The author has contributed to research in topics: Medicine & Cohort. The author has an hindex of 7, co-authored 15 publications. Previous affiliations of Marion Muche include Humboldt University of Berlin.
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Papers
Viscoelasticity-based staging of hepatic fibrosis with multifrequency MR elastography.
Patrick Asbach,Dieter Klatt,B. Schlosser,M Biermer,Marion Muche,A Rieger,Christoph Loddenkemper,Rajan Somasundaram,Thomas Berg,Bernd Hamm,Juergen Braun,Ingolf Sack +11 more
TL;DR: The diagnostic performance of multifrequency MR elastography in determining the degree of hepatic fibrosis increases with stage of fibrosis, and results of the AUROC analysis demonstrate the high accuracy of frequency-independent cutoff values for staging higher grades of liver fibrosis.
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The alpha 2 chain of collagen type VI sequesters latent proforms of matrix-metalloproteinases and modulates their activation and activity.
Christian Freise,Ulrike Erben,Marion Muche,Richard W. Farndale,Martin Zeitz,Rajan Somasundaram,Martin Ruehl +6 more
TL;DR: The alpha2(VI) chain modulates MMP availability by sequestering proMMPs in the ECM, blocking proteolytic activity, and might serve as a lead structure for MMP-based therapeutics which modulates the action of these matrix components, e.g. in fibrosis and cancer.
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Diagnostic performance of tomoelastography of the liver and spleen for staging hepatic fibrosis.
Rolf Reiter,Rolf Reiter,Heiko Tzschätzsch,Florian Schwahofer,Matthias Haas,Christian Bayerl,Marion Muche,Dieter Klatt,Shreyan Majumdar,Meltem Uyanik,Bernd Hamm,Jürgen Braun,Ingolf Sack,Patrick Asbach +13 more
TL;DR: Tomoelastography provides full-field-of-view elastograms of the abdomen with unprecedented detail resolution and excellent diagnostic accuracy for staging hepatic fibrosis and suggests that scan time can be further reduced in future studies, making tomoelastographic easier to implement in clinical routine.
Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42
Martin Ruehl,Marion Muche,Christian Freise,Ulrike Erben,Ulf Neumann,Detlef Schuppan,Yury Popov,Walburga Dieterich,Martin Zeitz,Richard W. Farndale,Rajan Somasundaram +10 more
TL;DR: Novel strategies using collagen analogs for the resolution of liver fibrosis via fibrotic matrix-sequestered gelatinases are suggested using triple helical and hydroxyproline-containing (GPO)10 unique in modulating gelatinase availability and activity.
Effectiveness and Safety of Direct-Acting Antiviral Combination Therapies for Treatment of Hepatitis C Virus in Elderly Patients: Results from the German Hepatitis C Registry
Georg Dultz,Tobias Müller,Jörg Petersen,Stefan Mauss,Tim Zimmermann,Marion Muche,Karl-Georg Simon,Thomas Berg,Stefan Zeuzem,Dietrich Hüppe,K Böker,Heiner Wedemeyer,Tania M. Welzel,Leberstiftungs-GmbH Deutschland +13 more
TL;DR: Direct-acting antiviral therapies were well tolerated in patients older than 70 years and differences in the prevalence of comorbidities between age groups warrant individualized attention with respect to drug–drug interactions and therapy adherence.
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